货号：MAB1923

品牌：Merck Millipore

规格：100Ug

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tenascin Antibody, type III repeats 4 and 5, clone 4F8 | MAB1923 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Binds to a recombinant fragment of human tenascin containing the fibronectin type III repeats, numbers 4 and 5. View All» Epitope: type III repeats 4 and 5 View All» Immunogen: Purified human tenascin View All» Clone: 4F8 View All» Isotype: IgG1κ View All» Species Reactivity: Human View All» Application Notes: Immunocytochemistry at 2 g/mL on U251 cells Immunoblotting (Western) at 2 g/mL to detect whole tenascin under reducing conditions ELISA: 2 x 10-10 M endpoint dilution Affinity constant Kd= 2 x 10-10 Final working dilutions must be determined by end user. View All» Presentation: Liquid in 0.02M Phosphate, 0.25M Sodium Chloride pH 7.6, with 0.1% Sodium Azide. View All» Storage Conditions: Maintain between 2 and 8°C for up to 6 months. View All» UniProt Number: P11215 View All» Entrez Gene Number: NM_000632.3 View All» Gene Symbol:

• ITGAM

• MO1A

• CD11b

• CR3A

• MAC1A

• CD11B

• MGC117044

• MAC-1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting

  • Immunocytochemistry
    View All» Entrez Gene Summary: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Some integrin alpha M proteins contain an inserted amino acid (Q, between AA positions 499 and 500) resulting from a 3bp shift in a splice acceptor that inserts the codon CAG; receptors with or without the extra amino acid are functionally indistinguishable View All» UniProt Summary: FUNCTION: SwissProt: P11215 # Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.SIZE: 1152 amino acids; 127179 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.DOMAIN: SwissProt: P11215 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Tenascin Antibody, type III repeats 4 and 5, clone 4F8 | MAB1923 View All» Concentration: 1mg/ml View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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