货号：05-1947

品牌：Merck Millipore

规格：EA

目录价：￥3024.00

市场价格：￥2570.40

会员价格：￥2419.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-USP7 Antibody, clone 7G9 | 05-1947 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Antibody recognizes the C-terminus of USP7. View All» Molecular Weight: 128 kDa View All» Epitope: C-terminus View All» Immunogen: His-tagged recombinant human protein corresponding to the C-terminus of USP7. View All» Clone: 7G9 View All» Isotype: IgG2bκ View All» Background Information: Ubiquitin carboxyl-terminal hydrolase 7(USP7) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates.[Saridakis, 2005] Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, Ubiquitin carboxyl-terminal hydrolase 7 activity generally stabilizes its substrate proteins. Ubiquitin carboxyl-terminal hydrolase 7 is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.[Canning, 2004] View All» Species Reactivity: Human View All» Species Reactivity Note: Reacts with Human. View All» Control: HeLa cell lysates View All» Quality Assurance: Evaluated by Western Blotting in HeLa cell lysates.Western Blotting Analysis: 0.25 µg/mL of this antibody detected USP7 in HeLa cell lysates. View All» Purification Method: Protein G purfied View All» Presentation: Purified IgG2bκ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q93009 View All» Entrez Gene Number: NM_003470.2 View All» Gene Symbol:

• USP7

• TEF1

• HAUSP
  View All» Alternate Names:
  • ubiquitin specific peptidase 7 (herpes virus-associated)

  • Ubiquitin-specific-processing protease 7

  • ubiquitin specific protease 7 (herpes virus-associated)

  • Herpesvirus-associated ubiquitin-specific protease

  • Herpes virus-associated ubiquitin-specific protease

  • Ubiquitin thioesterase 7

  • ubiquitin specific peptidase 7

  • Deubiquitinating enzyme 7

  • HAUSP
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: Cleaves ubiquitin fusion protein substrates. Deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. View All» Product Name: Anti-USP7, clone 7G9 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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