货号：05-1938

品牌：Merck Millipore

规格：

目录价：￥3821.00

市场价格：￥3247.85

会员价格：￥3056.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-G3BP1 Antibody, clone 14E5-G9 | 05-1938 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes G3BP1. View All» Molecular Weight: 52 kDa View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to human G3BP1. View All» Clone: 14E5-G9 View All» Isotype: IgG1κ View All» Background Information: G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. View All» Control: K562 cell lysate View All» Quality Assurance: Evaluated by Western Blot in K562 cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected G3BP1 on K562 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13283 View All» Entrez Gene Number: NP_005745.1 View All» Gene Symbol:

• G3BP

• G3BP-1

• HDH-VIII
  View All» Alternate Names:
  • ATP-dependent DNA helicase VIII

  • GAP SH3 domain-binding protein 1

  • GAP binding protein

  • GTPase activating protein (SH3 domain) binding protein 1

  • Ras-GTPase-activating protein SH3-domain-binding protein

  • RasGAP-associated endoribonuclease G3BP
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq] View All» UniProt Summary: FUNCTION: May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. COFACTOR: Magnesium. Required for helicase activity.SUBUNIT STRUCTURE: Binds to the SH3 domain of Ras GTPase-activating protein (RASA1) in proliferating cells. No interaction in quiescent cells Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP By similarity. Interacts with USP10, and may regulate it. Forms homodimers and oligomers.SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › cytosol. Cell membrane. Nucleus. Note: Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells By similarity. Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS.TISSUE SPECIFICITY: Ubiquitous.DOMAIN: The NTF2 domain mediates multimerization.PTM: Phosphorylated exclusively on serine residues. Hyperphosphorylated in quiescent fibroblasts. Hypophosphorylation leads to a decrease in endoribonuclease activity By similarity. RASA1-dependent phosphorylation of Ser-149 induces a conformational change that prevents self-association. Dephosphorylation after HRAS activation is required for stress granule assembly. Ser-149 phosphorylation induces partial nuclear localization.Arg-435 is dimethylated, probably to asymmetric dimethylarginine. SEQUENCE SIMILARITIES: Contains 1 NTF2 domain.Contains 1 RRM (RNA recognition motif) domain. View All» Product Name: Anti-G3BP1, clone 14E5-G9 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-130239.htm
      © Merck Millipore代理05-1938 Anti-G3BP1, clone 14E5-G9，产品报价联系微信jinshanbio