货号：9030

品牌：Merck Millipore

规格：250tubes

目录价：￥2232.00

市场价格：￥1897.20

会员价格：￥1785.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Glucagon View All» Qty/Pk: 250 tubes View All» Background Information: These iodinated hormonos are HPLC purified and prepared fresh monthly. View All» Application Notes: appropriate label hydrating buffer if kit replacement or assay buffer of choice View All» Entrez Gene Summary: The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. View All» UniProt Summary: FUNCTION: SwissProt: P01275 # Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.SIZE: 180 amino acids; 20909 Da SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.PTM: Proglucagon is post-translationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.SIMILARITY: SwissProt: P01275 ## Belongs to the glucagon family.MISCELLANEOUS: In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo." View All» Label: ¹²⁵Iodine View All» UniProt Number: P01275 View All» Radioactivity: View All» Storage Conditions: 2–8°C View All» Gene Symbol:

• GCG

• GLP1

• glucagon

• GRPP

• GLP2
  View All» Product Name: Glucagon View All» Entrez Gene Number: NM_002054.2 View All»
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