货号：MAB16983X

品牌：Merck Millipore

规格：

目录价：￥4280.00

市场价格：￥3638.00

会员价格：￥3424.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin α4 Antibody, clone P1H4, Alexa Fluor® 488 conjugated | MAB16983X View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody is reactive with integrin alpha4 from human and primate species. View All» Immunogen: Human T lymphocytes View All» Isotype: IgG1 View All» Background Information: The involvement of integrins in vascular proliferation, adhesion, and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. View All» Species Reactivity:

• Human

• Primate
  View All» Application Notes: Immunofluorescence: 2 μg/mL Flow cytometry Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in PBS containing 1% BSA, 0.05% Tween®-20 and 0.05% sodium azide. View All» Storage Conditions: Maintain at 2°-8°C for up to 12 months from date of receipt. View All» UniProt Number: P11215 View All» Entrez Gene Number: NM_000632.3 View All» Gene Symbol:
  • ITGAM

  • MO1A

  • CD11b

  • CR3A

  • MAC1A

  • CD11B

  • MGC117044

  • MAC-1
    View All» Alternate Names: CD49d View All» Usage Statement:
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      View All» Key Applications:
      • Flow Cytometry

      • Immunofluorescence
        View All» Entrez Gene Summary: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Some integrin alpha M proteins contain an inserted amino acid (Q, between AA positions 499 and 500) resulting from a 3bp shift in a splice acceptor that inserts the codon CAG; receptors with or without the extra amino acid are functionally indistinguishable View All» UniProt Summary: FUNCTION: SwissProt: P11215 # Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.SIZE: 1152 amino acids; 127179 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.DOMAIN: SwissProt: P11215 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin α4 Antibody, clone P1H4, Alexa Fluor® 488 conjugated | MAB16983X View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: AlexaFluor®488 View All» Host: Mouse View All»
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