货号：05-1917

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RSK2, clone 4RS-1B11 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Antibody recognizes the N-terminus of RSK2. View All» Molecular Weight: 84 kDa calculated, observed at 90 kDa. View All» Epitope: N-terminus View All» Immunogen: Ovalbumin conjugated linear peptide corresponding to the N-terminus of human RSK2. View All» Isotype: IgG1κ View All» Background Information: Rsk1, Rsk2, and Rsk3 (ribosomal protein S6 kinase, 90kDa, polypeptide 1,2,3; S6K-alpha 1,2,3) are Ser/Thr kinases which are activated by MAP Kinases, and are alternatively referred to as MAPKAP kinases 1a, 1b, and 1c. Following activation, Rsk isoforms translocate to the nucleus, where Rsk2 phosphorylates Ser10 of Histone H3, a critical step in the stimulation of immediate-early gene expression. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Reacts with Human, Mouse and Rat. View All» Application Notes: Immunocytochemistry anaylsis: 1:500 dilution from a previous lot detected RSK2 in C2C12 cells. View All» Control: L6 cell lysate View All» Quality Assurance: Evaluated by Western Blot in L6 cell lysate.Western Blot Analysis: 1:1000 of this antibody detected RSK2 on 10 µg of L6 lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified mouse monoclonal IgG1κ ascites with 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P51812 View All» Entrez Gene Number: BC096303 View All» Gene Symbol:
  • RPS6KA3

  • CLS

  • RSK2

  • p90-RSK2

  • ISPK1

  • MRX19

  • HU-3

  • pp90RSK2

  • MAPKAPK1B
    View All» Alternate Names:
    • p90RSK2

    • RSK-2

    • ribosomal protein S6 kinase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: Function Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.Catalytic activity ATP + a protein = ADP + a phosphoprotein.Cofactor Magnesium By similarity.Enzyme regulation Activated by multiple phosphorylations on threonine and serine residues By similarity.Subunit structure Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation By similarity. Interacts with NFATC4. Ref.10Tissue specificity Expressed in many tissues, highest levels in skeletal muscle.Post-translational modification Autophosphorylated on Ser-386, as part of the activation process By similarity. Ref.8 Ref.9 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.18Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369 By similarity.Involvement in disease Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations. Ref.19 Ref.20 Ref.21 View All» Product Name: Anti-RSK2, clone 4RS-1B11 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://16ao.com/thread-130163.htm
        © Merck Millipore代理05-1917 Anti-RSK-2, clone 4RS-1B11;已停产，产品报价联系微信jinshanbio