货号：MAB1682

品牌：Merck Millipore

规格：100UL

目录价：￥4239.00

市场价格：￥3603.15

会员价格：￥3391.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Actinin Antibody, α, clone AT6/172 | MAB1682 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human alpha actinin. This antibody recognizes an epitope in the N-terminal region of alpha-actinin, probably between residues 1-24. View All» Epitope: alpha View All» Immunogen: Human platelet protein View All» Clone: AT6/172 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Immunoblotting: ~100kDa on SDS reducing gels Immunoprecipitation Immunofluorescence: methanol fixed cells Immunohistochemistry Optimal working dilutions must be determined by end user. View All» Presentation: Liquid View All» Storage Conditions: Maintain frozen at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P12814 View All» Entrez Gene Number: NM_001102.2 View All» Gene Symbol:

• ACTN1

• FLJ40884

• Alpha-actinin-1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunofluorescence

  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. View All» UniProt Summary: FUNCTION: SwissProt: P12814 # F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.SIZE: 892 amino acids; 103058 Da SUBUNIT: Homodimer; antiparallel. Interacts with MYOZ2, PDLIM2 and TTID and LPP.SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z-disk. Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle.SIMILARITY: SwissProt: P12814 ## Belongs to the alpha-actinin family. & Contains 1 actin-binding domain. & Contains 2 CH (calponin-homology) domains. & Contains 2 EF-hand domains. & Contains 4 spectrin repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Actinin Antibody, α, clone AT6/172 | MAB1682 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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