货号：MAB1677

品牌：Merck Millipore

规格：100UL

目录价：￥3326.00

市场价格：￥2827.10

会员价格：￥2660.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytokeratin 17 Antibody, clone E3 | MAB1677 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human keratin 17, rat keratin with M.W. 40kD. Reveals myoepithelial cells, basal cells and proliferating epithelia in some benign epithelial tumors. View All» Immunogen: Keratin purified from rat enterocytes. View All» Clone: E3 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Immunohistochemistry on cultured cells (formalin-fixed) and frozen tissue. Also suitable for use on paraffin embedded tissue that has been fixed in ethanol. Immunoblotting Final working dilutions must be determined by end user. View All» Presentation: Liquid View All» Storage Conditions: Short term storage 1 month - +4°C. Long term storage - maintain frozen at -20°C for up to 12 months, aliquoted into convenient samples. Do not thaw and refreeze. View All» UniProt Number: Q04695 View All» Entrez Gene Number: NM_000422.1 View All» Gene Symbol:
  • KRT17

  • CK-17

  • PC2

  • Cytokeratin-17

  • PC

  • K17

  • Keratin-17

  • PCHC1

  • 39.1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: KRT17 encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. View All» UniProt Summary: FUNCTION: SwissProt: Q04695 # May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity).SIZE: 432 amino acids; 48106 Da SUBUNIT: Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers. Interacts with TRADD and SFN (By similarity).SUBCELLULAR LOCATION: Cytoplasm (By similarity).TISSUE SPECIFICITY: Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).DISEASE: SwissProt: Q04695 # Defects in KRT17 are a cause of pachyonychia congenita type 2 (PC2) [MIM:167210]; also known as Jadassohn-Lewandowsky (J- L) syndrome. PC2 is characterized by onchyogryposis, limited plantar hyperkeratosis, multiple epidermal cysts, abnormal eyebrow and body hair and by the presence of natal teeth. & Defects in KRT17 are a cause of steatocystoma multiplex (SM) [MIM:184500]. SM is a disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs. & KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.SIMILARITY: SwissProt: Q04695 ## Belongs to the intermediate filament family.MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). View All» Brand Family: Chemicon View All» Product Name: Anti-Cytokeratin 17 Antibody, clone E3 | MAB1677 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Distinguishes myoepithelial cells from luminal of various glands; Intramural cytotrophoblasts, from junctional zone trophoblast populations View All» Format: Ascites View All» Host: Mouse View All»
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