货号：MAB1622

品牌：Merck Millipore

规格：50Ug

目录价：￥7049.00

市场价格：￥5991.65

会员价格：￥5639.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Spectrin alpha chain (nonerythroid) Antibody, clone AA6 | MAB1622 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for the 240, 150, and 120 kDa forms of alpha-spectrin/alpha-fodrin molecule of all mammalian nonerythroid cells and chicken alpha-spectrin. View All» Molecular Weight: ~240 kDa full length product, ~150 kDa N-terminal cleaved product and ~120 kDa C-terminal product may be seen in varing amounts in lysates, depending on condition. The smaller sizes represent break down products seen during apoptosis. View All» Immunogen: Chicken red blood cell membranes purified by hypotonic lysis and mechanical enucleation. View All» Clone: AA6 View All» Isotype: IgG1 View All» Background Information: Non-erythroid Spectrin, also known as Fodrin, plays a role in stabilizing membrane structures, maintaining cell shape and linking the cytoskeleton to plasma membranes or intracellular vesicles. As one of the primary targets cleaved by activated caspases during apoptosis, the full-length ~240 kDa protein can be cleaved to yield an N-terminal product of ~150 kDa, and C-terminal products of ~120 and ~35 kDa. View All» Species Reactivity:

• Chicken

• Guinea Pig

• Human

• Mouse

• Rat

• Rabbit

• Pig

• Mammals
  View All» Species Reactivity Note: Chicken, Guinea Pig, Human, Mouse,Pig, Rat, and Rabbit. Wide-mammalian reactivity is expected. View All» Application Notes: Immunohistochemistry (IFA): A 1:200-1:400 dilution of a previous lot was used in immunohistochemistry.Does not work on paraffin sections.Optimal working dilutions must be determined by end user.Chromatin Immunopreciptiation: A previous lot of this antibody was used to immunoprecipitate Spectrin Alpha from chromatin-associated protein extracts derived from normal human, HeLa, FA-A, and transduced FA-A cells (McMahon, L.W., et al. (1999). J. Biological Chem. 274:32904-32908). View All» Applications Not Recommended: Immunohistochemistry (Paraffin) View All» Control: HeLa cells treated with staurosporine View All» Quality Assurance: Evaluated by Western Blot on staurosporine-treated HeLa lysates.Western Blot Analysis: 1:500 dilution of this antibody detected N-, C- terminal Spectrin alpha/Fodrin alpha on 10 μg of staurosporine treated HeLa lysates. View All» Purification Method: Protein A purfied View All» Presentation: Purified mouse monoclonal IgG1 in buffer containing PBS with 1% BSA and 0.09% sodium azide. View All» Storage Conditions: Stable for 12 months at 2-8°C from date of receipt. View All» UniProt Number: Q13813 View All» Entrez Gene Number: NM_003127.2 View All» Gene Symbol:
  • SPTAN1

  • FLJ44613

  • SPTA2
    View All» Alternate Names:
    • (ALPHA)II-SPECTRIN

    • Alpha-II spectrin

    • Fodrin alpha chain

    • Spectrin, non-erythroid alpha chain

    • non-erythrocytic spectrin alpha

    • spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

    • Fodrin α
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Immunoprecipitation

      • Western Blotting
        View All» UniProt Summary: FUNCTION: SwissProt: Q13813 # Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.SIZE:2472 amino acids; 284539 Da SUBUNIT: Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1.SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.PTM: Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro (By similarity).SIMILARITY: SwissProt: Q13813 ## Belongs to the spectrin family. & Contains 3 EF-hand domains. & Contains 1 SH3 domain. & Contains 23 spectrin repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Spectrin alpha chain (nonerythroid) Antibody, clone AA6 | MAB1622 View All» Concentration: 0.1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Mouse View All»
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        © Merck Millipore代理MAB1622 Anti-Spectrin alpha chain (nonerythroid) Antibody, clone AA6;抗血影蛋白α链（非红系）抗体，克隆AA6store at +2℃ to +8℃，产品报价联系微信jinshanbio