货号：MAB1612

品牌：Merck Millipore

规格：500Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytokeratin Epithelial Antibody, clone AE1 | MAB1612 View All» Replaces: CBL215 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes most of the acidic (Type I) keratins. It is broadly reactive and stains positively almost all epithelia and their neoplasms. MAB1612 produces heterogeneous staining within a given epithelium; the detailed staining pattern varies depending on the differentiated and/or growth state of individual cells. View All» Immunogen: Human epidermal keratin View All» Clone: AE1 View All» Isotype: IgG View All» Species Reactivity:

• Bovine

• Chicken

• Human

• Mouse

• Rat

• Rabbit
  View All» Application Notes: Immunohistochemistry on unfixed frozen sections and formalin-fixed paraffin embedded tissues. Antigen retrieval is recommended. HEIR or protease treatment can be used. Western Blotting: AE1 recognizes LMW cytokeratins from the acidic subfamily including: Clone AE1 recognises the 56.5, 50, 50', 48 and 40kD human cytokeratins of the acidic subfamily. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid in 0.05M Borate Buffered Saline, 0.15M NaCl, 0.09% Sodium Azide, pH8.2. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: P05787 View All» Entrez Gene Number: NM_002273.2 View All» Gene Symbol:
  • KRT8

  • KO

  • K8

  • CYK8

  • Keratin-8

  • CK-8

  • Cytokeratin-8

  • K2C8

  • CK8

  • CARD2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» UniProt Summary: FUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.SIZE: 483 amino acids; 53704 Da SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). View All» Brand Family: Chemicon View All» Product Name: Anti-Cytokeratin Epithelial Antibody, clone AE1 | MAB1612 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 µg View All» Target / Localization: Detects high molecular weight cytokeratins 10, 14, 15, 16 and low mw cytokeratin 19 View All» Format: Purified View All» Host: Mouse View All»
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