货号：MAB1587

品牌：Merck Millipore

规格：100Ug

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2 | MAB1587 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Glutamate Transporter EAAC1. Based on protein sequence the antibody is expected to react with mouse, bovine and rabbit. View All» Immunogen: C-terminus peptide (KDKSDTISFTQTSQF) (Catalog Number AG372). View All» Clone: 4D6.2 View All» Isotype: IgG1 View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1-2 μg/mL Immunohistochemistry: 1-2 μg/mL Optimal working dilutions must be determined by end user. EAAC1 is approximately 66-70kDa; the protein can form homomultimers during preparation as well, thus often times large 200-220kDa bands can also be seen. View All» Presentation: Purified immunoglobulin. Liquid in 0.02M Phosphate buffer, 0.25M NaCl, pH 7.6 with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C for up to six months. View All» UniProt Number: P43005 View All» Entrez Gene Number: NM_004170.4 View All» Gene Symbol:

• SLC1A1

• EAAC1

• EAAT3
  View All» Alternate Names: EAAT3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry

  • Western Blotting
    View All» UniProt Summary: FUNCTION: SwissProt: P43005 # Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).SIZE: 524 amino acids; 57100 Da SUBUNIT: Interacts with ARL6IP5/PRAF3 (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).PTM: Glycosylated.DISEASE: SwissProt: P43005 # Defects in SLC1A1 may be a cause of dicarboxylicamino aciduria [MIM:222730]; also known as glutamate-aspartate transport defect. This is as defect in renal and probably intestinal transport of glutamic and aspartic acids and is associated with moderate hyperprolinemia.SIMILARITY: SwissProt: P43005 ## Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. View All» Brand Family: Chemicon View All» Product Name: Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2 | MAB1587 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Target / Localization: Plasma Membrane View All» Format: Purified View All» Host: Mouse View All»
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