货号：MAB1532

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Hexokinase Type I Antibody, a.a. 191-209, clone 21 | MAB1532 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes a segmental epitope located between residues 191-209 of the Type I hexokinase sequence. View All» Epitope: a.a. 191-209 View All» Immunogen: Rat Type I hexokinase. View All» Clone: 21 View All» Isotype: IgG1 View All» Species Reactivity:

• Bovine

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:500-1:2,000. Immunolocalization of Type I hexokinase: 1:500-1:2,000. Optimal working dilutions must be determined by end user. View All» Storage Conditions: Store at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number:
  • P19367

  • P05708
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Western Blotting
      View All» Entrez Gene Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. View All» UniProt Summary: SIZE: 917 amino acids; 102486 Da SUBUNIT: Monomer.SUBCELLULAR LOCATION: Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding.TISSUE SPECIFICITY: Isoform 2 is erythrocyte specific; isoform 3 and isoform 4 are testis-specific.DOMAIN: SwissProt: P19367 The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.DISEASE:SwissProt: P19367 # Defects in HK1 are the cause of hexokinase deficiency [MIM:235700]. Hexokinase deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature.SIMILARITY: Belongs to the hexokinase family.MISCELLANEOUS: In vertebrates there are four major glucose- phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase)." View All» Brand Family: Chemicon View All» Product Name: Anti-Hexokinase Type I Antibody, a.a. 191-209, clone 21 | MAB1532 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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