货号：MAB1388Z

品牌：Merck Millipore

规格：

目录价：￥3721.00

市场价格：￥3162.85

会员价格：￥2976.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin β2 Antibody, clone YFC118.3, azide free | MAB1388Z View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB1388Z recognizes the human CD18 cell surface antigen, the integrin beta2 subunit. CD18 is expressed by the majority of leukocytes. View All» Clone: YFC118.3 View All» Isotype: IgG2b View All» Species Reactivity: Human View All» Application Notes: Flow Cytometry: 1:50 to 1:100. Immunohisology, frozen sections: 1:1000 to 1:5000. Does not work on paraffin sections. Immunoprecipitation Biological Activity:MAB1388Z blocks CD18-mediated homotypic adhesion. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid in phosphate buffered saline (pH7.2) containing no preservatives. View All» Storage Conditions: Store at -20°C in undiluted aliquots. Avoid repeated freeze-thaw cycles. View All» UniProt Number: P05107 View All» Entrez Gene Number: NM_000211.2 View All» Gene Symbol:

• ITGB2

• LFA-1

• MAC-1

• MF17

• LCAMB

• MFI7

• LAD

• CD18
  View All» Alternate Names:
  • CD18

  • MAB1388
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunoprecipitation

    • Immunohistochemistry

    • Affects Function
      View All» Entrez Gene Summary: The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. View All» UniProt Summary: FUNCTION: SwissProt: P05107 # Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1.SIZE: 769 amino acids; 84782 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.PTM: Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.DISEASE:SwissProt: P05107 # Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.SIMILARITY: SwissProt: P05107 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin β2 Antibody, clone YFC118.3, azide free | MAB1388Z View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rat View All»
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