货号：MAB13458

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-9 Antibody, clone 9D4.2 | MAB13458 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human MMP-9 pro and active forms. View All» Immunogen: Purified Human MMP-9 (Gelatinase B) View All» Clone: 9D4.2 View All» Isotype: IgG2a View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:200- 1:1000 Immunocytochemistry: Not Tested ELISA: 1:200-1:1000 Immunohistochemistry: Not Tested Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in PBS containing 0.01% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6/12 months. View All» UniProt Number: P14780 View All» Entrez Gene Number: NM_004994.2 View All» Gene Symbol:

• MMP9

• MMP-9

• GELB

• CLG4B

• EC 3.4.24.35 [Contains: 67 kDa matrix metalloproteinase-9

• 82 kDa matrix metalloproteinase-9].
  View All» Alternate Names: Gelatinase B; 92 kDa Type IV Collagenase View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. View All» UniProt Summary: FUNCTION: SwissProt: P14780 # May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond.COFACTOR: Binds 2 zinc ions per subunit. & Binds 3 calcium ions per subunit.SIZE: 707 amino acids; 78427 Da SUBUNIT: Exists as monomer, disulfide-linked homodimer, and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.TISSUE SPECIFICITY: Produced by normal alveolar macrophages and granulocytes.DOMAIN: SwissProt: P14780 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.SIMILARITY: Belongs to the peptidase M10A family. & Contains 3 fibronectin type-II domains. & Contains 4 hemopexin-like domains.MISCELLANEOUS: In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-9 Antibody, clone 9D4.2 | MAB13458 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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