货号：MAB13438

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-1 Antibody, clone 2A7.2 | MAB13438 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Antibody MAB13438 is directed against a synthetic peptide corresponding to the amino terminal region of human MMP-1. The antibody binds to MMP-1 but does not cross-react with the other MMP family members (MMP-2, MMP-3, MMP-9, etc.). SPECIES REACTIVITIES: Other species not tested; however this sequence of MMP-1 is well conserved across species. Higher concentrations of antibody may be needed for non-human samples. View All» Immunogen: Synthetic peptide corresponding to the amino terminal region of human MMP-1. View All» Clone: 2A7.2 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:1000 when using colorimetric substrates; 1:5,000 for chemiluminescent substrates. When used against the reduced protein, antibody MAB13438 recognizes bands at 53 kDa and 51 kDa (the pro-form), as well as active forms. ELISA Collagenase levels in quiescent cells and tissues is minimal, and stimulation or protein concentration is often needed to visualize the bands. In addition, cell types differ greatly in the quantity of collagenase produced. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid at 1 mg/mL containing 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P03956 View All» Entrez Gene Number: NM_002421.2 View All» Gene Symbol:

• MMP1

• CLG

• MMP-1

• CLGN

• EC 3.4.24.7 [Contains: 22 kDa interstitial collagenase

• 27 kDa interstitial collagenase].
  View All» Alternate Names: Fibroblast Collagenase; Interstitial Collagenase View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. View All» UniProt Summary: FUNCTION: SwissProt: P03956 # Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.COFACTOR: Binds 4 calcium ions per subunit. & Binds 2 zinc ions per subunit.SIZE: 469 amino acids; 54007 Da SUBUNIT: Interacts with HIV-1 Tat.SUBCELLULAR LOCATION: Secreted.DOMAIN: SwissProt: P03956 There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases). & The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MMP-1 Antibody, clone 2A7.2 | MAB13438 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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