货号：MAB13429

品牌：Merck Millipore

规格：1EA

目录价：￥5681.64

市场价格：￥4829.39

会员价格：￥4545.31

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TIMP-1 Antibody, clone 102D1 | MAB13429 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: It recognizes a glycoprotein of 28.5 kDa which is identified as tissue inhibitor of metalloproteinases-1 (TIMP-1). TIMP-1 and TIMP-2 have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenase, activated stromelysin, active form of 72 kDa type IV collagenase (also known as MMP-2 or gelatinase A), and latent and active forms 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. Cellular Localization: Cytoplasmic View All» Immunogen: Recombinant human TIMP-1. View All» Clone: 102D1 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Western Blotting: 1-2 μg/mL for 2 hours at room temperature Immunohistochemistry: Formalin-fixed, paraffin-embedded tissues: 1-2 μg/mL for 30 min. at room temperature. Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: Cytotrophoblastic columns, the endothelial and fibroblastic stromal cells of villi, and the large decidualized cells of decidual membrane in placenta1. View All» Presentation: Purified from ascites fluid by Protein G chromatography. Liquid in 10 mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months after date of receipt. View All» UniProt Number: P01033 View All» Entrez Gene Number: NM_003254.2 View All» Gene Symbol:

• TIMP1

• TIMP

• FLJ90373

• CLGI

• EPA

• EPO

• TIMP-1

• HCI
  View All» Alternate Names: Tissue Inhibitor of Metalloproteinase-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. View All» UniProt Summary: FUNCTION: SwissProt: P01033 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.SIZE: 207 amino acids; 23171 Da SUBCELLULAR LOCATION: Secreted.PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds.SIMILARITY: SwissProt: P01033 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain. View All» Brand Family: Chemicon View All» Product Name: Anti-TIMP-1 Antibody, clone 102D1 | MAB13429 View All» Concentration: 200 μg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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