货号：MAB1258

品牌：Merck Millipore

规格：

目录价：￥2644.00

市场价格：￥2247.40

会员价格：￥2115.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD36 Antibody, clone 63 | MAB1258 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with murine CD36. View All» Immunogen: Recombinant adenovirus vector containing cDNA for murine CD36 View All» Clone: 63 View All» Isotype: IgA View All» Background Information: CD36 is a major 88,000 MW platelet glycoprotein also found on monocytes, macrophages and some endothelial cells. It has multiple diverse roles in physiology. CD36 is a receptor for thrombospondin-1 (TSP-1), functioning as an inhibitor of angiogenesis. It also binds oxidized low density lipoproteins (LDL) and shed photoreceptor outer segments. CD36 is also act an endothelial-CAM acting in platelet adhesion and aggregration. Absence of CD36 protects against the formation of arterial plaques, thus slowing the development of atherosclerosis. CD36 transcription is regulated by the nuclear receptor PPAR-gamma. View All» Species Reactivity: Mouse View All» Application Notes: Immunofluorescence: 1:1000. Immunoprecipitation: 1:1000 Flow Cytometry: 1:1000 Functional Studies Optimal working dilutions must be determined by end user. View All» Control: POSITIVE: monocytes, macrophages NEGATIVE: Neural tissue; COS-7 cells View All» Presentation: Purified immunoglobulin presented as a liquid in PBS, pH 7.6, with 0.1% sodium azide. View All» Storage Conditions: Store at 2-8°C for up to 6 months from date of receipt. View All» UniProt Number: P16671 View All» Entrez Gene Number:

• NM_000072.2

• NM_001001547.1

• NM_001001548.1
  View All» Gene Symbol:
  • CD36

  • PAS-4

  • GPIV

  • FAT

  • CHDS7

  • GP3B

  • SCARB3

  • PASIV

  • GP4

  • GPIIIB
    View All» Alternate Names: Platelet Glycoprotein IV View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunofluorescence

    • Immunoprecipitation

    • Affects Function
      View All» Entrez Gene Summary: The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P16671 # Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.SIZE: 472 amino acids; 53053 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.PTM: N-glycosylated and O-glycosylated with a ratio of 2:1.DISEASE: SwissProt: P16671 # Defects in CD36 are the cause of platelet glycoprotein IV deficiency [MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. & Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].SIMILARITY: SwissProt: P16671 ## Belongs to the CD36 family. View All» Brand Family: Chemicon View All» Product Name: Anti-CD36 Antibody, clone 63 | MAB1258 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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