货号：MAB1254

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Chymase Antibody, clone B7 | MAB1254 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with human mast cell chymase. View All» Immunogen: Chymase purified from human skin. View All» Clone: B7 View All» Isotype: IgG1κ View All» Background Information: Mast cell chymase (EC 3.4.21.39), a member of the granzyme subfamily of the S1 family of peptidases, cleaves C-terminal to Phenylalanine, Tyrosine, Tryptophan, and Leucine residues (in order of preference). Chymase is stored in Mast cell granules within the cell and is the major secreated Mast cell protease. Secreated Mast cell chymase is believed to be involved in extracellular matrix degradation, vasoactive peptide generation, and regulation of gland secreation. View All» Species Reactivity: Human View All» Application Notes: Dot blotting: 0.5-1.0 μg/mL. Immunohistochemistry: 0.5-1.0 μg/mL. For optimal results, tissues or cytospin preparations should be fixed in Carnoy's Fluid (60% ethanol, 30% chloroform, 10% glacial acetic acid). Not recommended for use on formaldehyde fixed tissue. Not recommended for use on Western blots. Optimal working dilutions must be determined by end user. View All» Applications Not Recommended: Western Blotting View All» Control: POSITIVE CONTROL: lung, heart, skin, placenta. View All» Presentation: Purified by protein G affinity chromatography. Liquid in PBS with 20% glycerol, pH 7.4. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. Antibody may also be stored at -20ºC in undiluted aliquots. View All» UniProt Number: P23946 View All» Entrez Gene Number: NM_001836.2 View All» Gene Symbol:

• CMA1

• CYM

• MGC119890

• Alpha-chymase

• MCT1

• MGC119891

• CYH

• EC 3.4.21.39
  View All» Alternate Names: Mast Cell Protease I View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Dot Blot

  • Immunohistochemistry
    View All» Entrez Gene Summary: This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. View All» UniProt Summary: FUNCTION: SwissProt: P23946 # Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.SIZE: 247 amino acids; 27325 Da SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule. Note=Mast cell granules.TISSUE SPECIFICITY: Mast cells in lung, heart, skin and placenta.SIMILARITY: SwissProt: P23946 ## Belongs to the peptidase S1 family. Granzyme subfamily. & Contains 1 peptidase S1 domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Chymase Antibody, clone B7 | MAB1254 View All» Concentration: 2.4 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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