货号：MAB1222A

品牌：Merck Millipore

规格：100UL

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tryptase Antibody, Mast Cell, clone G3, Alkaline Phosphatase | MAB1222A View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Mast cell tryptase. Will show reactivity to basophils but to a lesser degree. View All» Clone: G3 View All» Isotype: IgG1κ View All» Species Reactivity: Human View All» Application Notes: Immunoblotting & immunohistochemistry at 1:200-1:1,000. For optimal results, tissues or cytospin preparations should be fixed in Carnoy's Fluid (60% ethanol, 30% chloroform, 10% glacial acetic acid). Not recommended for use on formaldehyde fixed tissue. May be used on thin sections prepared for ultrastructural analysis after fixation of tissue in a modified Karnovsky's reagent [Lab. Invest. (1988). 58:682-691]. Optimal working dilutions must be determined by end user. View All» Presentation: In 0.05M Tris + 0.1M NaCl + 0.001M MgCl2 with 0.1% NaN3, pH=8.0. View All» Storage Conditions: Maintain at +2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: Q15661 View All» Entrez Gene Number: NM_003294.3 View All» Gene Symbol:

• TPSAB1

• tryptase-I

• TPS2

• Tryptase-1

• TPSB1

• TPS1

• tryptase-III

• EC 3.4.21.59

• EC 3.4.21.59
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry
    View All» Entrez Gene Summary: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. View All» UniProt Summary: FUNCTION: SwissProt: P15157 # Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.| Q15661 # Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.SIZE: 275 amino acids; 30773 Da SUBUNIT: Homotetramer.SUBCELLULAR LOCATION: Secreted. Note=Released from the secretory granules upon mast cell activation.DOMAIN:SwissProt: P15157 SIMILARITY: SwissProt: P15157 ## Belongs to the peptidase S1 family. Tryptase subfamily. & Contains 1 peptidase S1 domain. | Q15661 ## Belongs to the peptidase S1 family. Tryptase subfamily. & Contains 1 peptidase S1 domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Tryptase Antibody, Mast Cell, clone G3, Alkaline Phosphatase | MAB1222A View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Alkaline Phosphatase View All» Host: Mouse View All»
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