货号：MAB1222

品牌：Merck Millipore

规格：100Ug

目录价：￥4746.00

市场价格：￥4034.10

会员价格：￥3796.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tryptase Antibody, Mast Cell, clone G3 | MAB1222 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Mast cell tryptase. Will show reactivity to basophils but to a lesser degree. View All» Molecular Weight: 31 kDa View All» Clone: G3 View All» Isotype: IgG1κ View All» Background Information: Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells. Tryptase has recently been used as a marker for mast cell activation and is involved with allergic response. Tryptase may act as a mitogen for fibroblast lines. Elevated levels of serum tryptase occur in both anaphylactic and anaphylactoid reactions, but a negative test does not exclude anaphylaxis. View All» Species Reactivity: Human View All» Application Notes: Flow Cytometry Analysis: A previous lot of this antibody has been used on fixed cells in FACS using a conjugated secondary antibody. (Sperr, W., et al., 2001).Optimal working dilutions must be determined by end user. View All» Control:

• Mast cells, basophils

• Human fetal skin lysate
  View All» Quality Assurance: Evaluated by western blot on human fetal skin lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected tryptase in 10 µg of human fetal skin lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.(see product datasheet for specific buffer formulation) View All» Storage Conditions: Maintain at 2–8°C for the duration listed on the product datasheet. (See product datasheet for storage conditions) View All» UniProt Number: Q15661 View All» Entrez Gene Number: NM_003294.3 View All» Gene Symbol:
  • TPSAB1

  • tryptase-I

  • TPS2

  • Tryptase-1

  • TPSB1

  • TPS1

  • tryptase-III

  • EC 3.4.21.59

  • EC 3.4.21.59
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. View All» UniProt Summary: FUNCTION: SwissProt: P15157 # Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.| Q15661 # Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.SIZE: 275 amino acids; 30773 Da SUBUNIT: Homotetramer.SUBCELLULAR LOCATION: Secreted. Note=Released from the secretory granules upon mast cell activation.DOMAIN:SwissProt: P15157 SIMILARITY: SwissProt: P15157 ## Belongs to the peptidase S1 family. Tryptase subfamily. & Contains 1 peptidase S1 domain. | Q15661 ## Belongs to the peptidase S1 family. Tryptase subfamily. & Contains 1 peptidase S1 domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Tryptase Antibody, Mast Cell, clone G3 | MAB1222 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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