货号：MAB1162F

品牌：Merck Millipore

规格：

目录价：￥4399.00

市场价格：￥3739.15

会员价格：￥3519.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-c-Kit Antibody, clone YB5.B8, FITC conjugated | MAB1162F View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes c-Kit (CD117, Steel factor receptor, and stem cell factor receptor), a transmembrane receptor tyrosine kinase expressed by hematopoietic progenitor cell subsets and mast cells. The interaction of c-Kit and its ligand is required for normal hematopoiesis, mast cell differentiation, melanogenesis, and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. View All» Molecular Weight: 120/145 kDa View All» Immunogen: Human M2 acute myeloid leukemia cells (Gadd, 1985) View All» Clone: YB5.B8 View All» Isotype: IgG1 View All» Background Information: c-Kit is a 145 kDa glycosylated transmembrane protein whose extracellular domain contains Ig-like domains that bind c-Kit ligand (KL; stem cell factor) to initiate signaling that programs mast cell proliferation, differentiation, migration, and survival. View All» Species Reactivity: Human View All» Application Notes: Flow cytometry: 10 μL/test Optimal working dilutions must be determined by end user. View All» Control: CCRF-HSB-2 whole cell lysate, human breast tumor tissue View All» Presentation: Fluorescein-conjugated purified immunoglobulin. Liquid in phosphate buffered saline containing 0.1% sodium azide and 1mg/mL bovine serum albumin. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Protect from Light. View All» UniProt Number: P10721 View All» Entrez Gene Number:

• NM_000222.2

• NM_001093772.1
  View All» Gene Symbol:
  • KIT

  • C-Kit

  • PBT

  • CD117

  • SCFR

  • c-kit

  • EC 2.7.10.1
    View All» Alternate Names: CD117; SCF Receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» Entrez Gene Summary: This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P10721 # This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).SIZE: 976 amino acids; 109865 Da SUBUNIT: Interacts with APS. Interacts with the tenth PDZ domain of MPDZ.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DISEASE: SwissProt: P10721 # Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. & Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. & Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).SIMILARITY: SwissProt: P10721 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Brand Family: Chemicon View All» Product Name: Anti-c-Kit Antibody, clone YB5.B8, FITC conjugated | MAB1162F View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 assays View All» Format: FITC View All» Host: Mouse View All»
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