货号：MAB11056

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Poly(rC)-binding protein 2 Antibody, clone 6A3.2 | MAB11056 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Poly(rC)-binding protein 2. View All» Molecular Weight: ~39 kDa View All» Epitope: aa 204-217 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Poly(rC)-binding protein 2. View All» Clone: 6A3.2 View All» Isotype: IgG3κ View All» Background Information: Poly(rC)-binding protein 2 (also known as αCP2 and hnRNP E2) is a part of a highly conserved, widely expressed family of RNA-binding proteins. Every isoform belonging to the Poly(rC)-binding protein family is comprised of a characteristic repeat of three KH domains, a 70 amino acid hnRNP commonly found in a large variety of RNA binding proteins. The KH domain is necessary to the binding of RNA. Poly(rC)-binding protein 2 functions to bind mRNA through its KH domain in a manner that provides a high level of stability to the mRNA. Recent studies have identified 160 mRNAs that are consistently and specifically associated with Poly(rC)-binding protein 2 (Waggoner,2003). Expression of Poly(rC)-binding protein 2 has been observed in all tissues tested. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution of this antibody has been shown to detect Poly(rC)-binding protein 2 in A431 cells. View All» Control: Hek293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in Hek293 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Poly(rC)-binding protein 2 on 10 µg of Hek293 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15366 View All» Entrez Gene Number: NP_001122383 View All» Gene Symbol:
  • hnRNP-E2

  • HNRPE2

  • alpha-CP2
    View All» Alternate Names:
    • poly(rC) binding protein 2

    • heterogenous nuclear ribonucleoprotein E2

    • poly(rC)-binding protein 2

    • Alpha-CP2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Major cellular poly(rC)-binding protein. Binds also poly(rU).SUBUNIT STRUCTURE: Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. TISSUE SPECIFICITY: Detected in all tissues examined.PTM: Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.SS=EQUENCE SIMLARITIES: Contains 3 KH domains. View All» Product Name: Anti-Poly(rC)-binding protein 2, clone 6A3.2 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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