货号：MAB11024

品牌：Merck Millipore

规格：EA

目录价：￥3348.00

市场价格：￥2845.80

会员价格：￥2678.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FUSE-binding protein 3 Antibody, clone 3B2.2 | MAB11024 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FUSE-binding protein 3. View All» Molecular Weight: 61 kDa Observed View All» Epitope: Unknown View All» Immunogen: Linear peptide corresponding to human FUSE-binding protein 3. View All» Clone: 3B2.2 View All» Isotype: IgG1κ View All» Background Information: FUSE binding protein 3, also known as far upstream element (FUSE) binding protein 3, or FBP3 is a single-stranded nucleic acid binding protein. There are three known FUSE binding proteins (FBP1, FBP2, and FBP3). All three belong to an ancient family of single-stranded DNA binding proteins. These proteins are required for regulation of the c-myc proto-oncogene and have been shown to bind to an A/T-rich element (far-ustream element) located 1.7 kb upstream of the c-myc P2 promoter. Although their primary sequences are closely related, the FBP, FBP2, and FBP3 genes are located on different chromosomes in both mice and humans. FUSE binding proteins are believed to be multifunctional. Besides regulating the transcription of c-myc (and quite likely other targets), the FBP family has been shown to bind a variety of RNAs in vitro. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected FUSE-binding protein 3 in NIH/3T3, HeLa, and A431 cells. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected FUSE-binding protein 3 on 10 µg of HEK293 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96I24 View All» Entrez Gene Number: NP_003925.1 View All» Gene Symbol:
  • FUBP3

  • FBP3
    View All» Alternate Names:
    • FUSE-binding protein 3

    • far upstream element (FUSE) binding protein 3

    • far upstream element binding protein 3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.SUBCELLULAR LOCATION: Nucleus Probable. TISSUE SPECIFICITY: Detected in a number of cell lines.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE SIMILARITIES: Contains 4 KH domains.SEQUENCE CAUTION: The sequence AAC50893.1 differs from that shown. Reason: Frameshift at position 18. The sequence AAH01325.1 differs from that shown. Reason: Frameshift at position 527. View All» Product Name: Anti-FUSE-binding protein 3, clone 3B2.2 Antibody (MAB11024) View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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