货号：MAB11012

品牌：Merck Millipore

规格：

目录价：￥4621.00

市场价格：￥3927.85

会员价格：￥3696.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CBX-4 Antibody, clone 10H10.2 | MAB11012 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CBX-4. View All» Molecular Weight: 61 kDa View All» Immunogen: The immunogen was GST-tagged fusion protein containing amino acids 77-551 of murine CBX-4. View All» Clone: 10H10.2 View All» Isotype: IgG2bκ View All» Background Information: Chromeobox 4 (CBX4), also known as Pc2, is a polycomb group (PcG) protein that functions as a transcriptional suppressor. CBX4 is thought to act as a co-repressor of DNMT3B, inducing transcriptional repression independent of DNA methylation. CBX4 also acts as a SUMO E3 ligase, facilitating SUMO1 conjugation by UBE2I. CBX4 is phosphorylated on Thr495 by HIPK2 upon DNA damage, which enhances its E3 SUMO-protein ligase activity. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse. Does not react with rat View All» Non-Reactive Species: Rat View All» Application Notes: Luminex®:The antibody was shown to bind CBX4, but not CBX7 or CBX8, by Luminex® assay. View All» Control: HeLa nuclear extract or NIH3T3 whole cell lysate View All» Quality Assurance: Western Blot Analysis:1 μg/mL of this antibody detected CBX-4 on 20 ug of NIH3T3 cell lysate and HeLa nuclear extract. View All» Purification Method: Purified from ascites by protein G affinity chromatography. View All» Presentation: Purified mouse monoclonal IgG2bκ in PBS containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O00257 View All» Entrez Gene Number: NM_007625 View All» Gene Symbol:
  • PC2

  • NBP16

  • Pc2

  • hPC2

  • hPc2
    View All» Alternate Names: chromobox homolog 4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Multiplexing
      View All» UniProt Summary: Function: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Pathway: Protein modification; protein sumoylation.Subunit structure: Interacts with histone H3-K9Me3 By similarity. Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Interacts with SUV39H1 and HIPK2.Subcellular location: Nucleus. Tissue specificity: Ubiquitous.Post-translational modification: Phosphorylated on Thr-495 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-492. Sequence similarities: Contains 1 chromo domain. View All» Product Name: Anti-CBX-4, clone 10H10.2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-129708.htm
      © Merck Millipore代理MAB11012 ANTI-CBX-4，产品报价联系微信jinshanbio