货号：MAB1077

品牌：Merck Millipore

规格：

目录价：￥4095.00

市场价格：￥3480.75

会员价格：￥3276.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DYNLT3 Antibody, clone 10A3C8A1 | MAB1077 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Reacts with rat DYNLT3 (dynein light chain Tctex-type 3). View All» Molecular Weight: ~13 kDa View All» Immunogen: Full-length recombinant rat DYNLT3 protein View All» Clone: 10A3C8A1 View All» Isotype: IgG2aκ View All» Background Information: Eukaryotic cells rely on actin and microtubule-based protein "motors" to generate intracellular movements. These motor proteins contain specialized domains that hydrolyse ATP to produce force and movement along a cytoskeletal polymer (microtubules in the case of the kinesin family and dyneins) In all cell types, dynein is a large protein complex composed of six distinct subunits and is responsible for most intracellular movement toward the minus ends of microtubules. Cytoplasmic dynein has many important roles in transporting membrane bound organelles, including endosomes, lysosomes, and mitochondria. It is also involved in the positioning of the centrosome, the nucleus, and the Golgi. Cytoplasmic dynein is also responsible for virus transport to the nucleus, retrograde axonal transport, and microtubule and neurofilament transport.Three families of dynein light chains (DYNLT) have been identified. Two isoforms of the DYNLT family of light chains, DYNLT1 and DYNLT3, have been proposed to link dynein to specific cargoes. Recent publications indicate that DYNLT3 binds to Bub3, a spindle checkpoint protein and Bub3 binds exclusively to DYNLT3 and not to other dynein light chains. DYNLT3 is present on kinetochores at prometaphase, but not later mitotic stages.It has been suggested that a subpopulation of dynein, containing the DYNLT3 light chain, may have a role in the transport of checkpoint proteins from the kinetochore to the spindle pole, (W.-Ho, 2007). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Reacts with rat and human. Other species have not been tested. View All» Control: Rat brain lysate View All» Quality Assurance: Evaluated on a representative lot by Western blot in rat brain lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified in 0.1M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% NaN3. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: Q5XI90 View All» Entrez Gene Number: NP_001013246.1 View All» Gene Symbol:
  • RP3

  • TCTE1L

  • TCTE1XL

  • TCTEX1L
    View All» Alternate Names:
    • Protein 91/23

    • T-complex-associated testis-expressed 1-like

    • dynein, light chain, Tctex-type 3

    • t-complex-associated-testis-expressed 1-like
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Product Name: Anti-DYNLT3 Antibody, clone 10A3C8A1 | MAB1077 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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