货号：MAB1049

品牌：Merck Millipore

规格：100Ug

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2 | MAB1049 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for bone morphogenetic protein-4 (BMP-4) by Western blot and ELISA. No cross-reactivity with human BMP-2 or human TGF-β1. The antibody reacts with both human and mouse BMP-4 in both reduced and nonreduced conditions. Human BMP-4 (accession number P12644) precursor (389 aa, glycosilated) consists of a propeptide (273 aa) and active BMP-4 (116 aa, glycoslyated; MW reduced 17-20 kDa). View All» Molecular Weight: 17 kDa View All» Immunogen: Recombinant mouse BMP-4 (Masuhara, 1995). View All» Clone: 3H2 View All» Isotype: IgG2b View All» Background Information: Bone morphogenetic protein 4 (BMP4) is a polypeptide belonging to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. It has been shown to be involved in muscle development, bone mineralization, and uteric bud development. BMP4 has also been implicated in Fibrodysplasia Ossificans Progressiva in which it is underexpressed. In human embryonic development, BMP4 is a critical signalling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures. BMP4 stimulates differentiation of overlying ectodermal tissue. Inhibition of the BMP4 signal (by chordin, noggin, or follistatin) causes the ectoderm to differentiate into the neural plate. If these cells also receive signals from FGF, they will differentiate into the spinal cord; in the absence of FGF the cells become brain tissue. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Immunocytochemistry using osteoinductive cells; i.e., BFP and Saos-2 Western blot using osteoinductive cells; i.e., BFP and Saos-2 Optimal working dilutions must be determined by the end user. View All» Control: Mouse brain extract View All» Purification Method: Protein A purfied View All» Presentation: Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative. View All» Storage Conditions: Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P12644 View All» Entrez Gene Number:
  • NM_001202.3

  • NM_130850.2

  • NM_130851.2
    View All» Gene Symbol:
    • BMP4

    • BMP2B1

    • BMP2B

    • BMP-4

    • DVR4

    • BMP-2B

    • ZYME
      View All» Alternate Names: BMP-4; DVR-4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Immunocytochemistry

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. View All» UniProt Summary: FUNCTION: SwissProt: P12644 # Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair.SIZE: 408 amino acids; 46555 Da SUBUNIT: Homodimer; disulfide-linked (By similarity). Interacts with GREM2 (By similarity) and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD (By similarity).SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.TISSUE SPECIFICITY: Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.SIMILARITY: SwissProt: P12644 ## Belongs to the TGF-beta family. View All» Brand Family: Chemicon View All» Product Name: Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2 | MAB1049 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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