货号：MAB1048

品牌：Merck Millipore

规格：

目录价：￥6559.00

市场价格：￥5575.15

会员价格：￥5247.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1 | MAB1048 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Bone morphogenetic protein 6 (BMP-6) is a member of the TGF-b superfamily of cytokines regulating homeotic gene expression, embryonic development and neurogenesis. MAB1048 recognizes BMP-6. Pre-incubation of MAB1048 with amino-terminal peptide 1-29 of BMP-6 inhibits binding of the monoclonal to tissue sections. Pre-incubation with other amino-terminal synthetic peptides of human BMP-7, BMP-4, BMP-3 and BMP-2 as well as irrelevant peptides does not inhibit specific tissue staining. The antigen is highly conserved phylogenetically and is thus anticipated to react with most mammalian species. View All» Molecular Weight: 45/18 kDa View All» Immunogen: Synthetic peptide vgr 1-29C-KLH. View All» Clone: Morph-6.1 View All» Isotype: IgG1 View All» Background Information: Bone morphogenetic protein 6 (BMP6) is a polypetide that is a member of the TGF-β superfamily of proteins. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells. View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Immunohistochemistry: 1-5 μg/mL. Fixation: formaldehyde, paraffin. Tissue pretreatment: microwave treatment (6 x 5) min is required. Optimal working dilutions must be determined by the end user. View All» Control: Embryonic and adult central nervous system, rat radial glial cells, fetal intestine, healing skin or chondrocytes View All» Presentation: Purified immunoglobulin from culture supernatant. Lyophilized from PBS containing 5 mg/mL BSA and 0.09% sodium azide. Reconstitute with 0.5 mL of sterile distilled water. View All» Storage Conditions: Maintain lyophilized material at 2-8°C for up to 12 months after date of receipt. After reconstitution maintain at -20*C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P22004 View All» Entrez Gene Number: NM_001718.4 View All» Gene Symbol:
  • BMP6

  • VGR1

  • BMP-6

  • VGR
    View All» Alternate Names: BMP-6; DVR-6 (Decapentaplegic Vegetal Related); vgr-1 (vegetal related) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» Entrez Gene Summary: The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. View All» UniProt Summary: FUNCTION: SwissProt: P22004 # Induces cartilage and bone formation.SIZE: 513 amino acids; 57226 Da SUBUNIT: Interacts with SOSTDC1 (By similarity).SUBCELLULAR LOCATION: Secreted (By similarity).SIMILARITY: SwissProt: P22004 ## Belongs to the TGF-beta family. View All» Brand Family: Chemicon View All» Product Name: Anti-Bone Morphogenetic Protein 6 Antibody, clone Morph-6.1 | MAB1048 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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