货号：MAB10421

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Plexin-A2 Antibody, clone 2G1.1 | MAB10421 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~260 kDa observed. 211 kDa calculated. This protein runs at a higher molecular weight due to glycosylation (Renaud, J., et al. (2008). Nat Neurosci. 11(4):440-449). View All» Immunogen: KLH-conjugated linear peptide corresponding to human Plexin-A2. View All» Clone: 2G1.1 View All» Isotype: IgMκ View All» Background Information: Plexin-A2 is a member of the transmembrane semaphorin receptor family which is associated with the guidance of the axon during development. Plexin-A2 may also be involved in the regulation of neuronal plasticity and regeneration and is thought to play a role in schizophrenia. Plexin-A2 has also been linked to certain anxiety disorders. Plexin-A2 associates with semaphorin to regulate centrosome positioning and therefore control cell migration. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Rat. View All» Control: Mouse fetal brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse fetal brain tissue lysate.Western Blot Analysis: A 1:500 dilution of this antibody detected Plexin-A2 on 10 µg of mouse fetal brain tissue lysate. View All» Purification Method: Ion exchange View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O75051 View All» Entrez Gene Number: NP_079455 View All» Gene Symbol:
  • PLXNA2

  • OCT

  • PLXN2
    View All» Alternate Names:
    • Plexin-A2

    • Semaphorin receptor OCT
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). SUBUNIT STRUCTURE: Interacts directly with NRP1 and NRP2 By similarity. Interacts with RND1.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential. TISSUE SPECIFICITY: Detected in fetal brain. SEQUENCE SIMILARITIES: Belongs to the plexin family.Contains 4 IPT/TIG domains.Contains 1 Sema domain.SEQUENCE CAUTION: The sequence BAA32308.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. View All» Product Name: Anti-Plexin-A2, clone 2G1.1 View All» Concentration: 0.18 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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