货号：MAB10419

品牌：Merck Millipore

规格：100Ug

目录价：￥4316.00

市场价格：￥3668.60

会员价格：￥3452.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Plexin-A1 Antibody, clone 14A1.2 | MAB10419 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~211 kDa observed View All» Immunogen: GST-tagged recombinant protein corresponding to human Plexin-A1. View All» Clone: 14A1.2 View All» Isotype: IgG1κ View All» Background Information: Although Plexin-A1 is a semaphorin receptor that is most commonly expressed in dendritic cells, it is most recognized as a proprioceptive sensory axon-specific receptor for Semaphorin-6C and Semaphorin-6D. Its most prominent role for sema6C/6D-plexinA1 signaling in sensory neuron development appears to be in the control of proprioceptive axon shaft position. In the absence of Plexin-A1 a breakdown of the exclusion of proprioceptive axon shafts from the superficial dorsal horn is observed, but without an impact on axon collateral trajectory. Plexin-A1 appears to be involved in T cell activation and may play a role in angiogenesis. A potential marker for dendritic cell maturity, Plexin-A1 has been found in the cytoplasm of the immature dendritic cells while localizing to the membranes of the mature ones. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Plexin-A1 on 10 µg of HEK293 cell lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9UIW2 View All» Entrez Gene Number: NP_115618 View All» Gene Symbol:

• PLXNA1

• NOV

• PLXN1

• PLEXIN-A1

• NOVP
  View All» Alternate Names:
  • Plexin-A1

  • Semaphorin receptor NOV
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity).SIZE: 1896 amino acids; 211087 Da SUBUNIT: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).TISSUE SPECIFICITY: Detected in fetal brain, lung, liver and kidney.SIMILARITY: Belongs to the plexin family. & Contains 4 IPT/TIG domains. & Contains 1 Sema domain. View All» Product Name: Anti-Plexin-A1, clone 14A1.2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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