货号:MAB10418
品牌:Merck Millipore
规格:EA
目录价:¥3828.00
市场价格:¥3253.80
会员价格:¥3062.40
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Description:
Anti-TRAIL-R2 Antibody, clone YM366 | MAB10418
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Promotional Text:
Special Shipping Offer on Antibodies100% Performance Guaranteed
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Molecular Weight:
48 kDa calculated
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Immunogen:
Histidine-tagged recombinant protein corresponding to human TRAIL-R2.
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Clone:
YM366
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Isotype:
IgG1κ
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Background Information:
TRAIL-R2 is also known as soluble Death Receptor 5 (sDR5), a single-pass type I membrane protein belonging to the tumor necrosis factor receptor superfamily and is comprised of a single death domain and three TNFR-Cys repeats. Through association of its death domain to cytotoxic ligand TRAIL and related receptor DR4, TRAIL-R2 is a component of the preapoptotic death-inducing signaling complex, the formation of which induces proteolytic activation of caspase-8 resulting in regulated apoptosis. TRAIL-R2 also upregulates the activation of NF-kappa-B. It is expressed in a wide variety of fetal and adult tissues including heart, liver, pancreas, testis, esophagus, prostate, ovary, stomach, spleen, thymus and peripheral blood lymphocytes. It is not expressed in the brain. Defects in TRAIL-R2 are thought to cause head and neck squamous cell carcinomas (HNSCC).
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Species Reactivity:
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Human
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Mouse
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Species Reactivity Note:
Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology.
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Control:
Jurkat cells
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Quality Assurance:
Evaluated by Flow Cytometry in Jurkat cells.Flow Cytometry Analysis: 2 µg of this antibody detected TRAIL-R2 in Jurkat cells.
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Purification Method:
Protein G
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Presentation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
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Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
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UniProt Number:
O14763
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Entrez Gene Number:
NP_003833
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Gene Symbol:
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TNFRSF10B
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KILLER/DR5
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TRICKB
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TRANCE-R
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TRICK2
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ZTNFR9
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DR5
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TRAIL-R2
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TRICK2B
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TRAILR2
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KILLER
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TRICK2A
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Alternate Names:
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tumor necrosis factor receptor superfamily member 10b
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soluble Death Receptor 5
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sDR5
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CD262
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p53-regulated DNA damage-inducible cell death receptor (killer)
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death domain containing receptor for TRAIL/Apo-2L
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cytotoxic TRAIL receptor-2
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tumor necrosis factor receptor-like protein ZTNFR9
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TNF-related apoptosis-inducing ligand receptor 2
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Flow Cytometry
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Entrez Gene Summary:
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq].
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UniProt Summary:
FUNCITON: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.SUBUNIT STRUCTURE: Homotrimer. Can interact with TRADD and RIP.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 and G361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.INDUCTION: TNFRSF10B is regulated by the tumor suppressor p53.INVOLVEMENT IN DISEASE: Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.SEQUENCE SIMILARITIES: Contains 1 death domain.Contains 3 TNFR-Cys repeats.
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Product Name:
Anti-TRAIL-R2, clone YM366
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Concentration:
1 mg/mL
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Antibody Type:
Monoclonal Antibody
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Qty/Pk:
100 μg
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Format:
Purified
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Host:
Mouse
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