货号：MAB10402

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Plexin B1 Antibody, clone 19A7.1 | MAB10402 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~230 kDa observed View All» Immunogen: GST-tagged recombinant protein corresponding to human Plexin B1. View All» Clone: 19A7.1 View All» Isotype: IgMκ View All» Background Information: Plexin B1 is a member of the plexin family of proteins that are receptors for semaphorins, repulsive axon guidance molecules. Plexin B1 binds activated Rac and binds Rho when clustered causing stress fiber development. Plexin B1 may play a part in follicular growth and steroidogenesis in mouse ovaries. It is believed to play a role in trophoblast-endometrium interactions by increasing adhesion properties. Furthermore, Plexin B is thought to effect mouse development and tumor induced angiogenesis although it is excessive and not strictly required. Plexin B1 has also been shown to inhibit ovarian cancer cell movement and invasion when silenced. View All» Species Reactivity:

• Mouse

• Rat

• Human
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: 1:50 dilution from a representative lot detected Plexin B1 in normal human, normal mouse, and normal rat brain tissues. Weak staining was also observed at 1:250. A dilution between 1-50 and 1-250 would be optimal. View All» Control: Rat brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Plexin B1 on 10 µg of rat brain tissue lysate. View All» Purification Method: Ion Exchange View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O43157 View All» Entrez Gene Number: NP_001123554 View All» Gene Symbol:
  • SEP

  • plexin 5

  • PLXN5

  • PLXNB1
    View All» Alternate Names:
    • plexin B1

    • plexin-B1

    • PLEXIN-B1

    • Semaphorin receptor SEP
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. SUBUNIT STRUCTURE: Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Interacts with ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RRAS, RHOD, RND1, NRP1 and NRP2. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 2: Secreted Isoform 3: Secreted TISSUE SPECIFICITY: Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. PTM: Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding. Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.SEQUENCE SIMILARITIES: Belongs to the plexin family.Contains 3 IPT/TIG domains.Contains 1 Sema domain.SEQUENCE CAUTION: The sequence BAA23703.2 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Plexin B1, clone 19A7.1 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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