货号：MAB10139

品牌：Merck Millipore

规格：100UL

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LIM Domain Only 2 Antibody, clone 2E6 | MAB10139 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human View All» Molecular Weight: 18kDa View All» Immunogen: Recombinant human LMO2 View All» Clone: 2E6 View All» Isotype: IgG2a View All» Background Information: LIM Domain only 2 (LMO2) encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Liquid containing 0.1% sodium azide. View All» Storage Conditions: 1 year at 4°C from date of shipment View All» UniProt Number: P25791 View All» Entrez Gene Number: NM_005574.2 View All» Gene Symbol:

• LMO2

• RHOM2

• TTG2

• RBTN2

• Rhombotin-2

• RBTNL1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. View All» UniProt Summary: FUNCTION: SwissProt: P25791 # Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.SIZE: 158 amino acids; 18358 Da SUBUNIT: Interacts via its LIM domains with ELF2 and LBD1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and JARID1A.SUBCELLULAR LOCATION: Nucleus (Potential).DOMAIN: SwissProt: P25791 The second LIM zinc-binding domain interacts with JARID1A.DISEASE:SwissProt: P25791 # A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.SIMILARITY: Contains 2 LIM zinc-binding domains. View All» Brand Family: Chemicon View All» Product Name: Anti-LIM Domain Only 2 Antibody, clone 2E6 | MAB10139 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Culture Supernatant View All» Host: Mouse View All»
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