货号：MAB10134

品牌：Merck Millipore

规格：

目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PAX8, clone 3G11 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 43 kDa View All» Immunogen: Recombinant human PAX8 View All» Clone: 3G11 View All» Isotype: IgG2b View All» Background Information: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Optimal working dilutions must be determined by end user. View All» Presentation: Liquid containing 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C for up to 12 months from date of receipt. View All» UniProt Number: Q06710 View All» Entrez Gene Number:
  • NM_003466.3

  • NM_013951.3

  • NM_013952.3

  • NM_013953.3

  • NM_013992.3
    View All» Gene Symbol: PAX8 View All» Alternate Names: Paired box protein Pax-8 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternateively spliced transcript variants encoding different isoforms have been described. View All» UniProt Summary: FUNCTION: SwissProt: Q06710 # Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.SIZE: 450 amino acids; 48119 Da SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Expressed in the excretory system, thyroid gland and Wilms tumors.DEVELOPMENTAL STAGE: In developing excretory system, during thyroid differentiation and in adult thyroid.DISEASE: SwissProt: Q06710 # Defects in PAX8 are a cause of thyroid dysgenesis (TD) [MIM:218700]. TD is the most frequent cause of congenital hypothyroidism (CH). The thyroid gland can be absent (athyreosis), ectopically located (most often at the base of the tongue) and/or severely reduced in size (hypoplasia).SIMILARITY: SwissProt: Q06710 ## Contains 1 paired domain. View All» Brand Family: Chemicon View All» Product Name: Anti-PAX8, clone 3G11 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Culture Supernatant View All» Host: Mouse View All»
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