货号：MAB10100

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MSX1, clone 1E2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 31kDa View All» Immunogen: Recombinant human MSX1 View All» Clone: 2E5 View All» Isotype: IgG View All» Background Information: The Msx genes are a family of homeobox genes related to the Drosophila msh (muscle segment homeobox)-like gene family. The Msx homeobox genes are thought to play an important role in vertebrate organogenesis. Amongst this family, Msx1 is a fundamental factor for craniofacial skeleton formation and tooth morphogenesis. View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Liquid containing 0.1% sodium azide. View All» Storage Conditions: 1 year at 2-8°C from date of shipment View All» UniProt Number: P28360 View All» Entrez Gene Number: NM_002448.3 View All» Gene Symbol:
  • MSX1

  • Hox-7

  • HOX7

  • HYD1

  • OFC5
    View All» Alternate Names: HOX7, HYD1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. View All» UniProt Summary: FUNCTION: SwissProt: P28360 # Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.SIZE: 297 amino acids; 30940 Da SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Expressed in the developing nail bed mesenchyme.DISEASE: SwissProt: P28360 # Defects in MSX1 are a cause of autosomal dominant hypodontia (HYD1) [MIM:106600]; also known as familial or selective tooth agenesis. Absence of less than 6 teeth is referred to as hypodontia. Agenesis of one or more teeth constitutes one of the most common developmental anomalies in man. Reported incidences vary from 1.6% to 9.6%, excluding third molar (Wisdom tooth) agenesis, which occurs in 20% of the population. & A chromosomal aberration involving MSX1 is a cause of Wolf-Hirschhorn syndrome (WHS) [MIM:194190]. WHS is caused by sub- telomeric deletions in the short arm of chromosome 4. WHS is characterized by profound mental retardation, heart defects, and facial clefting. & Defects in MSX1 are the cause of Witkop syndrome (WITS) [MIM:189500]. WITS is a form of ectodermal dyslasia also called tooth-and-nail syndrome or dysplasia of nails with hypodontia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. Witkop syndrome is characterized by abnormalities largely limited largely to teeth (some of which are missing) and nails (which are poorly formed early in life, especially toenails). This condition is distinguished from anhidrotic ectodermal dysplasia by autosomal dominant inheritance and little involvement of hair and sweat glands. The teeth are not as severely affected. & Defects in MSX1 are the cause of non-syndromic orofacial cleft 5 (OFC5) [MIM:608874]; also called non-syndromic cleft lip with or without cleft palate 5. Non-syndromic orofacial cleft (OFC) [MIM:119530] is a common birth disorder affecting 1 in every 700 live births. Defects in MSX1 are associated with clefting, selective hypodontia or dental anomalies with other ectodermal features.SIMILARITY: SwissProt: P28360 ## Belongs to the Msh homeobox family. & Contains 1 homeobox DNA-binding domain. View All» Brand Family: Chemicon View All» Product Name: Anti-MSX1, clone 1E2 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Culture Supernatant View All» Host: Mouse View All»
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