货号：MAB082-1F7.2

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Lipoprotein (a) Antibody, clone 1F7.2 | MAB082-1F7.2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Lp(a), human. View All» Immunogen: Lp(a), human. View All» Clone: 1F7.2 View All» Isotype: IgG2a View All» Species Reactivity: Human View All» Application Notes: ELISA. Optimal working dilutions must be determined by the end user. View All» Presentation: Liquid. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots up to 12 months.Avoid repeated freeze/thaw cycles. View All» UniProt Number: P08519 View All» Entrez Gene Number: NM_005577.2 View All» Gene Symbol:

• LPA

• Apolipoprotein

• a

• aprecursor

• a.

• Lp

• Apo

• LP

• apolipoprotein(a)

• APOA

• AK38

• EC 3.4.21.-
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: ELISA View All» UniProt Summary: FUNCTION: SwissProt: P08519 # Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.SIZE: 4548 amino acids; 501319 Da SUBUNIT: Disulfide-linked to apo-B100. Binds to fibronectin and decorin.PTM: N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O- glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected.DISEASE: SwissProt: P08519 # Elevated plasma concentrations of apo(a) and its naturally occurring proteolytic fragments are correlated with atherosclerosis. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.SIMILARITY: SwissProt: P08519 ## Belongs to the peptidase S1 family. Plasminogen subfamily. & Contains 38 kringle domains. & Contains 1 peptidase S1 domain.MISCELLANEOUS: Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation. View All» Brand Family: Chemicon View All» Product Name: Anti-Lipoprotein (a) Antibody, clone 1F7.2 | MAB082-1F7.2 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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