货号：MAB079-1

品牌：Merck Millipore

规格：100UL

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-S-100 Protein Antibody, clone 15E2E2 | MAB079-1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes intact, alpha and beta subunits of bovine, human, and murine S-100 protein, as determined by immunoprecipitation profiles. View All» Epitope: Recognizes both alpha & beta S100 View All» Immunogen: Purified bovine S-100 protein View All» Clone: 15E2E2 View All» Isotype: IgG2aκ View All» Background Information: S-100 protein is a member of the EF-hand calcium-binding protein superfamily that is widely distributed and conserved in the central nervous system of vertebrates. The protein exists in both heterodimeric and homodimeric forms. The two subunits of S-100 protein are the products of separate genes that are differentially expressed by various cells. The beta subunit is present in all S-100 positive cells and tumors. In contrast, the alpha subunit is detectable only in heart, skeletal muscle and brain. In addition to its calcium binding properties, S-100 protein has a high-affinity binding site for zinc and is involved in the regulation of protein phosphorylation in the brain. The protein apparently plays a role in cell differentiation and growth, cytoskeletal structure and function, and has been implicated in neuropathological diseases. View All» Species Reactivity:

• Human

• Bovine

• Mouse

• Rat

• Canine

• Rabbit

• Feline
  View All» Species Reactivity Note: Bovine, human, mouse, and rat. View All» Application Notes: Immunoprecipitation: A previous lot of this antibody was used in IP.Visualization of cellular and subcellular localization of S-100 protein using immunohistochemical techniques.Immunohistochemistry: A 1:100-200 dilution of a previous lot was used for paraffin embedded tissue sections. Optimal working dilutions must be determined by end user. View All» Control: Positive Control Tissue: Melanoma View All» Quality Assurance: Evaluated by Western Blot on PC12 lysatesWestern Blot Analysis: 1:1000 dilution of this antibody detected S100 on 10 µg of PC12 lysate. View All» Purification Method: Protein A purfied View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing PBS, pH 7.6, 1% BSA and 0.09% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P23297 View All» Entrez Gene Number: NM_006271.1 View All» Gene Symbol:
  • S100A1

  • S100A

  • S100

  • S100-alpha
    View All» Alternate Names: Calcium Binding Protein A1/B1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. View All» UniProt Summary: FUNCTION: SwissProt: P23297 # Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.SIZE: 94 amino acids; 10546 Da SUBUNIT: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.SIMILARITY: SwissProt: P23297 ## Belongs to the S-100 family. & Contains 2 EF-hand domains. View All» Brand Family: Chemicon View All» Product Name: Anti-S-100 Protein Antibody, clone 15E2E2 | MAB079-1 View All» Concentration: Variable View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All» Packaging: @ 1 mg/mL concentation View All»
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      © Merck Millipore代理MAB079-1 Anti-S-100 Protein Antibody, clone 15E2E2;抗S-100蛋白抗体，克隆15E2E2store at +2℃ to +8℃，产品报价联系微信jinshanbio