货号：M-003259

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: E2F-1 SMARTpool® siRNA reagent View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 5 nmol View All» Product Overview: For questions or concerns regarding the use of the SMARTpools®, please contact Dharmacon Technical Support, 1-800-235-9880, email: lab@dharmacon.com. View All» Key Applications: RNAi/siRNA/Gene Knockdown View All» Application Notes: SMARTpools® are the collection of at least four individual siRNA duplexes targeted against a specific gene and designed using a bioinformatics technology known as SMARTselection™, resulting in the generation of siRNAs that function more than 97% of the time. The targeted message level is reduced by more than 70% 24 hours after transfection. For use in human cell lines. View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. View All» UniProt Summary: FUNCTION: SwissProt: Q01094 # Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.SIZE: 437 amino acids; 46920 Da SUBUNIT: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T- antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A.SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.SIMILARITY: SwissProt: Q01094 ## Belongs to the E2F/DP family. View All» Brand Family: Upstate View All» Sales Restrictions: This product is not available for sale in Australia, New Zealand, Singapore, Indonesia, Thailand, The Phillippines, Malaysia, Vietnam, Japan, Korea, and China. View All» UniProt Number: Q01094 View All» Gene Symbol:

• E2F1

• RBAP-1

• RBBP-3

• RBP3

• E2F-1

• RBBP3

• PBR3
  View All» Product Name: E2F-1 SMARTpool® siRNA reagent View All» Entrez Gene Number: NM_005225.1 View All»
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