货号：M-003211

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: CCND2 (Cyclin D2) SMARTpool® siRNA reagent View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 5 nmol View All» Product Overview: For questions or concerns regarding the use of the SMARTpools®, please contact Dharmacon Technical Support, 1-800-235-9880, email: lab@dharmacon.com. View All» Key Applications: RNAi/siRNA/Gene Knockdown View All» Application Notes: SMARTpools® are the collection of at least four individual siRNA duplexes targeted against a specific gene and designed using a bioinformatics technology known as SMARTselection™, resulting in the generation of siRNAs that function more than 97% of the time. The targeted message level is reduced by more than 70% 24 hours after transfection. For use in human cell lines. View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. View All» UniProt Summary: FUNCTION: SwissProt: P24385 # Essential for the control of the cell cycle at the G1/S (start) transition.SIZE: 295 amino acids; 33729 Da SUBUNIT: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.DISEASE: SwissProt: P24385 # A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle. & A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer. & A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t(11;14)(q13;q32) with the IgH locus.SIMILARITY: SwissProt: P24385 ## Belongs to the cyclin family. Cyclin D subfamily. View All» Brand Family: Upstate View All» Sales Restrictions: This product is not available for sale in Australia, New Zealand, Singapore, Indonesia, Thailand, The Phillippines, Malaysia, Vietnam, Japan, Korea, and China. View All» UniProt Number: P24385 View All» Gene Symbol:

• CCND1

• PRAD1

• BCL1

• D11S287E

• U21B31
  View All» Product Name: CCND2 (Cyclin D2) SMARTpool® siRNA reagent View All» Entrez Gene Number: NM_053056.2 View All»
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