货号：348083

品牌：BD IS

规格：100T

目录价：￥4565.00

市场价格：￥3195.50

会员价格：￥2967.25

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Catalog Number

348083

Name

CD42a

Size

100Tests

RegulatoryStatus

RUO (GMP)

Clone

Beb1

Format

FITC

Isotype

IgG₁, κ

W.S. No

none

W.B. Positive Control

none

Molecular Weight

none

Reactivity

QC Testing : Human

Applications

Flow cytometry

- Routinely Tested

Clone - Description

CD42a recognizes a 17- to 22-kDa single-chain, platelet membrane glycoprotein, also known as gpIX, that forms a noncovalent complex with gpIb and gpV. Glycoprotein Ib consists of an a-chain disulfide-linked to a b chain. Glycoproteins Iba (140 to 145 kDa), Ibb (24 to 25 kDa), and V (82 to 86 kDa) have been designated as CD42b, CD42c, and CD42d respectively. CD42a has been reported to react with both gpIX and the gpIb-IX-V complex.The gpIX along with gpIb and gpV are members of the leucine-rich glycoprotein (LRG) family of proteins, each of which is encoded by a separate gene. The function of the gpIb-IX-V complex is essential for normal platelet adhesion and activation. The gpIb-IX-V complex contains a binding site for von Willebrand factor (vWf) that mediates the activation-independent, shear-dependent adhesion of platelets to the exposed vascular subendothelium. The gpIb-IX-V complex functions as a high affinity thrombin binding site. The glycoprotein Ib-IX-V complex functions as an attachment site anchoring the plasma membrane to its subjacent cytoskeleton, thereby stabilizing the membrane and maintaining platelet shape and vWf function.The CD42a antigen is present on resting and activated platelets and on megakaryocytes. Resting platelets display approximately 25,000 copies each of gpIba and gpIX and 11,000 copies of gpV. Downregulation of the platelet surface gpIb-IX-V complex in whole blood occurs upon activation via rapid redistribution of gpIb-IX-V to the surface-connected canalicular system (SCCS).Downregulation of vWf binding to gpIb-IX-V, following platelet activation, may be an important pathway biasing platelets toward aggregation over vessel wall adhesion. The gpIb-IX-V complexes are absent or quantitatively decreased in platelets of patients with the Bernard-Soulier syndrome, a bleeding disorder characterized by giant platelets, reduced ristocetin-dependent binding of vWf, reduced adhesion to sub-endothelium and vWf, and decreased platelet response to activation by thrombin.