货号：340535

品牌：BD IS

规格：200ug

目录价：￥8560.00

市场价格：￥5992.00

会员价格：￥5564.00

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Catalog Number

340535

Name

PAC-1

Size

200µg

RegulatoryStatus

RUO (GMP)

Clone

PAC-1

Format

Purified

Isotype

IgM, κ

W.S. No

none

W.B. Positive Control

none

Molecular Weight

none

Reactivity

QC Testing : Human

Applications

Flow cytometry	- Routinely Tested
Immunohistochemistry	- Routinely Tested

Clone - Description

PAC-1 recognizes an epitope on the glycoprotein IIb/IIIa (gpIIb/IIIa, a_IIbb₃)complex of activated platelets at or near the platelet fibrinogen receptor. The gpIIb/IIIa complex is a member of a family of heterodimeric adhesive protein receptors found on a variety of cell types that have been named the integrin or the cytoadhesion family.The gpIIb/IIIa complex is located on the surface membrane of resting platelets. Platelet activation induces a calcium-dependent conformational change in gpIIb/IIIa that exposes a ligand binding site. Four adhesive macromolecules are capable of interacting with the activated form of gpIIb/IIIa: fibrinogen, von Willebrand factor (vWf), fibronectin, and vitronectin. The binding of fibrinogen to the gpIIb/IIIa receptor is required for platelet aggregation. PAC-1 binds only to activated platelets and appears to be specific for this recognition site within gpIIb/IIIa. Approximately 45,000 to 50,000 gpIIb/IIIa receptors appear on the platelet surface upon activation. PAC-1 inhibits fibrinogen- mediated platelet aggregation.