BD IS代理340507 PAC-1 FITC荧光单克隆抗体试剂

2025-06-28

货号:340507

品牌:BD IS

规格:50T

目录价:¥2283.00

市场价格:¥1598.10

会员价格:¥1483.95

金山科研平台,产品价格货期咨询微信:jinshanbio

Catalog Number
340507
Name
PAC-1
Size
50Tests
RegulatoryStatus
RUO (GMP)
Clone
PAC-1
Format
FITC
Isotype
IgM, κ
W.S. No
none
W.B. Positive Control
none
Molecular Weight
none
Reactivity
QC Testing : Human
Applications
Flow cytometry - Routinely Tested
Clone - Description

PAC-1 recognizes an epitope on the glycoprotein IIb/IIIa (gpIIb/IIIa, aIIbb3)complex of activated platelets at or near the platelet fibrinogen receptor. The gpIIb/IIIa complex is a member of a family of heterodimeric adhesive protein receptors found on a variety of cell types that have been named the integrin or the cytoadhesion family.The gpIIb/IIIa complex is located on the surface membrane of resting platelets. Platelet activation induces a calcium-dependent conformational change in gpIIb/IIIa that exposes a ligand binding site. Four adhesive macromolecules are capable of interacting with the activated form of gpIIb/IIIa: fibrinogen, von Willebrand factor (vWf), fibronectin, and vitronectin. The binding of fibrinogen to the gpIIb/IIIa receptor is required for platelet aggregation. PAC-1 binds only to activated platelets and appears to be specific for this recognition site within gpIIb/IIIa. Approximately 45,000 to 50,000 gpIIb/IIIa receptors appear on the platelet surface upon activation. PAC-1 inhibits fibrinogen- mediated platelet aggregation.

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