eBioscience (含Bender)代理12-0333-82 Anti-Mouse Siglec H PE 100 ug；价格见Thermo同编号产品-试剂-金山科研平台

eBioscience (含Bender)代理12-0333-82 Anti-Mouse Siglec H PE 100 ug；价格见Thermo同编号产品

2025-06-25

货号：12-0333-82

品牌：eBioscience (含Bender)

规格：100ug

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio

Description: The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG).It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.

Host	Rat
Isotype	IgG2b
Reactivity	Mouse
Conjugate	PE
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Excite	488 - 561 nm
Legal	Pat. No. pending
Reported Applications	Flow Cytometric Analysis

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