货号：701031

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：EACH

目录价：￥4692.00

市场价格：￥4222.80

会员价格：￥4222.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This purified ABfinity™ recombinant rabbit monoclonal antibody, clone 11HCLC, recognizes IL-22 in human samples.ABfinity™ antibody characteristics include:• Validation in Western blot and and Indirect ELISA• Superior lot-to-lot consistency• Extremely high specificity and sensitivity• Recombinant rabbit monoclonal antibodySpecific for IL-22 Interleukin-22 (IL-22) belongs to the IL-10 family of regulatory cytokines, which are mainly produced by terminally differentiated T-helper 17 (TH17) cells (Ref 1, 2). It is highly expressed during chronic inflammation (Ref 1). IL-22 and its receptor also activate intracellular kinases and transcription factors, chiefly STAT3 (Ref 3-4). In humans, the gene encoding IL-22 is located on the q arm of chromosome 12 (Ref 5).Exceptional Consistency Saves You Time and MoneyABfinity™ antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.High Specificity Means More Reliable DataThe proprietary recombinant technology employed in the production of ABfinity™ antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved. Invitrogen has validated this antibody in Western blotting.High Sensitivity Lets You Detect Low Levels of Target ProteinABfinity™ antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.Recombinant Rabbit IgG—Use Like Any Other IgG AntibodyAs with traditional IgG antibodies, gel electrophoresis of ABfinity™ antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.Related Links:Learn more about the superior performance of ABfinity™ recombinant monoclonal antibodies.See Life Technologies' full line of ABfinity™ recombinant monoclonal antibodies.References:• Zenewicz LA, Flavell RA. IL-22 and inflammation: leukin' through a glass onion. Eur J Immunol. 2008 Dec;38(12):3265-8. Review. PubMed PMID: 19016525.• Wolk K, Kunz S, Asadullah K, Sabat R. Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol. 2002 Jun 1;168(11):5397-402. PubMed PMID: 12023331.• Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, Lehr HA, Hirth S, Weigmann B, Wirtz S, Ouyang W, Neurath MF, Becker C. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med. 2009 Jul 6;206(7):1465-72. Epub 2009 Jun 29. PubMed PMID: 19564350.• Ziesché E, Bachmann M, Kleinert H, Pfeilschifter J, Mühl H. The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells. J Biol Chem. 2007 Jun 1;282(22):16006-15. Epub 2007 Apr 16. PubMed PMID: 17438334.• Dumoutier L, Van Roost E, Ameye G, Michaux L, Renauld JC. IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Immun. 2000 Dec;1(8):488-94. PubMed PMID: 1119769. 规格

Reactivity:	Human
Validated Application:	ELISA,Western Blot
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	11H16L16
Antibody Fragment:	Whole Antibody
Target Gene:	IL-22
Gene ID:	50616
Label or Dye:	Unconjugated
Form:	Liquid
Neutralizing Antibody:	No
Product Size:	100 µg
Protein Family:	Cytokines & Receptors
Research Category:	Immunology
Shipping Condition:	Approved for shipment on Wet or Dry Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.