货号：700505

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：EACH

目录价：￥4772.00

市场价格：￥4294.80

会员价格：￥4294.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 The purified rabbit anti-human HIF1-alpha Monoclonal Antibody, ABfinity™ Recombinant recognizes HIF1-alpha in human samples and based on sequence homology reactivity with mouse is expected. HIF1-alpha (Hypoxia-inducible factor 1, alpha), a subunit HIF1, which is a transcription factor found in mammalian cells cultured under reduced oxygen tension. HIF1 functions as a transcriptional regulator of the adaptive response to hypoxia. This rabbit anti-human HIF1-alpha Monoclonal Antibody, ABfinity™ Recombinant can be used in applications such as Western Blot, Immunofluorescence and Flow Cytometry.• Applications: Validated applications for rabbit anti-human HIF1-alpha Monoclonal Antibody, ABfinity™ Recombinant are Western Blot, Immunofluorescence and Flow Cytometry.• Host species and isotype: The host species and isotype of the rabbit anti-human HIF1-alpha Monoclonal Antibody, ABfinity™ Recombinant is rabbit IgG.• Clone ID of monoclonal antibody (mAb): The rabbit anti-human HIF1-alpha Monoclonal Antibody, ABfinity™ Recombinant clone is 16H4L13.• Reactivity: Rabbit anti-human HIF1-alpha Monoclonal Antibody, ABfinity™ Recombinant detects human (mouse) HIF1-alpha.• Product size: Rabbit anti-human HIF1-alpha Monoclonal Antibody, ABfinity™ Recombinant is available in a 100 µg pack size.ABfinity™ antibody characteristics include:• Validation in Western Blot, Immunofluorescence and Flow Cytometry• Superior lot-to-lot consistency• Extremely high specificity and sensitivity• Recombinant rabbit monoclonal antibodySpecific for HIF1-alphaHIF1-alpha (Hypoxia-inducible factor 1, alpha), a subunit of HIF1, is a transcription factor found in mammalian cells cultured under reduced oxygen tension. It regulates the adaptive response to hypoxia and hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis. Hypoxia induces p53 protein accumulation and reduces hypoxia-induced expression of HIF1-alpha by promoting MDM2-mediated ubiquitination and proteasomal degradation. Recent studies suggest that induction of NOX4 by HIF1-alpha contributes to maintenance of ROS levels after hypoxia and hypoxia-induced proliferation. In humans, the gene encoding HIF1-alpha is located on the q arm of chromosome 14.Exceptional Consistency Saves You Time and MoneyABfinity™ antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.High Specificity Means More Reliable DataThe proprietary recombinant technology employed in the production of ABfinity™ antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved. Life Technologies has validated this antibody in Western Blot, Immunofluorescence and Flow Cytometry.High Sensitivity Lets You Detect Low Levels of Target ProteinABfinity™ antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.Recombinant Rabbit IgG—Use Like Any Other IgG AntibodyAs with traditional IgG antibodies, gel electrophoresis of ABfinity™ antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions. 规格

Reactivity:	Human
Validated Application:	Flow Cytometry,Immunofluorescence,Western Blot
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	16H4L13
Antibody Fragment:	Whole Antibody
Target Gene:	HIF1 Alpha
Gene ID:	3091
Gene Symbol:	HIF1A
Accession Number:	Q16665
Label or Dye:	Unconjugated
Purification:	Purified
Form:	Liquid
Mass:	100 µg
Neutralizing Antibody:	No
Product Size:	100 μg
Protein Family:	Transcription Factors
Research Category:	Signal Transduction
Shipping Condition:	Approved for shipment on Wet or Dry Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.