货号：700384

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：100 UG

目录价：￥4600.00

市场价格：￥4140.00

会员价格：￥4140.00

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 Connexin 46 (Cx46) is a monoclonal antibody specific to mouse, rat, hamster Connexin 46. This antibody is validated for use in Western Blot and Immunohistochemistry. Connexin 46 is encoded by the 14611 gene, also known as gap junction protein, alpha 3, Cx46, Connexin 46, Cx43, Cnx46, Gja-3, gap junction protein, alpha 3, Cx46, Connexin 46, Cx43, Cnx46, Gja-3.Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46 and C2P3, maps to human chromosome 13q11-q12 and encodes a 46 kDa protein. Cx46, along with Cx50, is principally expressed in the lens of the eye (1). Cx46 mediates intercellular interactions during development and is necessary for the survival of neural crest cells (2). Cx46 forms gap junctions that connect lens fiber cells and are crucial for maintaining lens transparency (3) and normal lens function (4). Mutations of Cx46 result in severe cataracts of the lens (5,6). Individual knockouts of Cx46 and Cx50 lead to changes in the rate of lens fiber cell differentiation and cell size, thus the interaction of Cx46 and Cx50 is required for proper organization of fiber cells (7).White TW. (2002) Unique and redundant connexin contributions to lens development. Science 295:319-320.Bannerman P, et al. (2000) Early migratory rat neural crest cells express functional gap junctions: Evidence that neural crest cell survival requires gap junction function. J Neurosci Res 61: 605-615.Hopperstad MG, et al. (2000) Properties of gap junction-channels formed by Cx46 alone and in combination with Cx50. Biophys J 79: 1954-1966.Pal JD, et al. (2000) Connexin 46 mutations linked to congenital cataract show loss of gap junction channel function. Am J Physiol Cell Physiol 279: C596-602. Mackay, D et al. (1999) Connexin46 mutations in autosomal dominant congenital cataract. Am J Hum Genet 64: 1357-1364.Jiang H, et al. (2003) A novel mutation in GJA3 (connexin46) for autosomal dominant congenital nuclear pulverulent cataract Mol Vision 9:579-593, 2003.Dunia, I. et al. (2006) Structural and immunocytochemical alterations in eye lens fiber cells from Cx46 and Cx50 knockout mice. Eur. J. Cell Biol. 85: 729-752. 规格

Reactivity:	Mouse
Validated Application:	Western Blot,Immunohistochemistry
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	11H16L33
Antibody Fragment:	Whole Antibody
Target Gene:	Connexin 46
Gene ID:	14611
Accession Number:	Q64448
Label or Dye:	Unconjugated
Purification:	Affinity Purified
Concentration:	0.5 mg⁄ml
Color:	Unconjugated
Neutralizing Antibody:	No
Product Size:	100 µg
Quantity:	1 each
Volume:	200 µl
Shipping Condition:	Approved for shipment on Wet or Dry Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.