货号：700366

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：100 UG

目录价：￥4692.00

市场价格：￥4222.80

会员价格：￥4222.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 ABfinity™ Recombinant Rabbit Monoclonal Antibody is validated with human and is expected to detect mouse RIG-I. This antibody is validated for use in Western Blot. RIG-I is encoded by the 230073 gene, also known as DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIG-I, C330021E21, 6430573D20Rik, Ddx58. Retinoic acid-inducible gene I, RIG-I is a pattern recognition receptor (PRR) involved in the recognition of viral dsRNA (1). Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both MDA5 and RIG-I are RNA helicases and they perform overlapping as well as distinct roles. RIG-I is activated by dsRNAs without a 5’-triphosphate end and short dsRNAs, whereas MDA5 is activated by long dsRNAs (2). Once activated, both proteins signal through IPS-1 activating transcription factors NF-κB and IRF-3 (1) and ultimately activating apoptosis, cytokine signaling, and inflammation (3). RIG-I is essential for signaling by influenza A, influenza B, human respiratory syncytial virus (3), paromyxoviruses, Japanese encephalitis virus (4), and West Nile virus (5). MicroRNA-146a has been implicated in feedback inhibition of RIG-I-dependant antiviral response by negatively regulating RIG-I targets TRAF6, IRAK1, and IRAK2 (6). Recent evidence has implicated RIG-I in the detection of cytosolic DNA through RNA polymerase III activity (7,8).Yoneyama, M. et al. (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5: 730-737.Kato, H. et al. (2008) Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J. Exp. Med. 205: 1601-1610.Loo, Y-M. et al. (2008) Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J. Virol. 82: 335-345.Kato, H. et al. (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441: 101-105.Fredericksen, B.L. (2008) Establishment and maintenance of the innate antiviral response to West Nile virus involves both RIG-I and MDA5 signaling through IPS-1. J. Virol. 82:609-616.Hou, J. et al. (2009) MicroRNA-146a feedback inhibits RIG-I-dependent type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J. Immunol. 183: 2150-2158.Chiu, Y-H, et al. (2009) RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138: 576-591.Ablasser, A. et al. (2009) RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat. Immunol. 10: 1065-1073. 规格

Reactivity:	Human
Validated Application:	Western Blot
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	35H2L48
Antibody Fragment:	Whole Antibody
Target Gene:	RIG-I
Gene ID:	230073
Accession Number:	Q6Q899
Label or Dye:	Unconjugated
Purification:	Affinity Purified
Concentration:	0.5 mg⁄ml
Form:	Liquid
Neutralizing Antibody:	No
Product Size:	100 µg
Quantity:	1
Volume:	200 µl
Shipping Condition:	Approved for shipment on Wet or Dry Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.