货号：700158

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：EACH

目录价：￥4692.00

市场价格：￥4222.80

会员价格：￥4222.80

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This purified ABfinity™ recombinant rabbit monoclonal antibody, clone 15H4L7, recognizes Histone 2A in human and mouse.ABfinity™ antibody characteristics include:• Validation in Western blot• Superior lot-to-lot consistency• Extremely high specificity and sensitivity• Recombinant rabbit monoclonal antibodyClone ID: 15H4L7Specific for Histone 2AHistones are nuclear proteins that play an important role in maintaining the structure of the chromosome in eukaryotes (Ref 1). The nucleosome is made up of around 146bp of DNA, which enfolds a histone octomer unit made up of four major histones, H2A, H2B, H3, and H4. An important role of H2A is to ensure proper assembly and functioning of the centrometre (Ref 2), and it plays a role in gene regulation. The H2A protein can be modified by acetylation and phosphorylation (Ref 3).Exceptional Consistency Saves You Time and Money ABfinity™ antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.High Specificity Means More Reliable DataThe proprietary recombinant technology employed in the production of ABfinity™ antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved. Invitrogen has validated this antibody in Western blotting.High Sensitivity Lets You Detect Low Levels of Target ProteinABfinity™ antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.Recombinant Rabbit IgG—Use Like Any Other IgG AntibodyAs with traditional IgG antibodies, gel electrophoresis of ABfinity™ antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.For research use only. Not intended for any human or animal therapeutic or diagnostic use.Related Links:Learn more about the superior performance of ABfinity™ recombinant monoclonal antibodiesSee Invitrogen's full line of ABfinity™ recombinant monoclonal antibodiesReferences:1. Ausió J. Histone variants—the structure behind the function. Brief Funct Genomic Proteomic. 2006 Sep;5(3):228-43. Epub 2006 May 10. Review. PubMed PMID: 16772274.2. Pinto I, Winston F. Histone H2A is required for normal centromere function in Saccharomyces cerevisiae. EMBO J. 2000 Apr 3;19(7):1598-612. PubMed PMID: 10747028.3. Pantazis P, Bonner WM. Quantitative determination of histone modification. H2A acetylation and phosphorylation. J Biol Chem. 1981 May 10;256(9):4669-75. PubMed PMID: 7217105. 规格

Reactivity:	Human
Validated Application:	ELISA,Western Blot
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Monoclonal
Clone ID:	15H4L7
Antibody Fragment:	Whole Antibody
Target Gene:	Histone 2A
Gene ID:	8331, 8329, 3013, 85235, 3012
Accession Number:	Q99878
Label or Dye:	Unconjugated
Purification:	Purified
Form:	Liquid
Mass:	100 µg
Neutralizing Antibody:	No
Product Size:	100 µg
Protein Family:	Transcription Factors
Research Category:	Signal Transduction
Shipping Condition:	Approved for shipment on Wet or Dry Ice

内容及储存 2-8°C for up to 1 month, -20°C for long term storage. Avoid repeated freezing and thawing.