货号：44887G

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：100 UL BIOSOURCE (TM)

目录价：￥3600.00

市场价格：￥3240.00

会员价格：￥3240.00

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 This rabbit anti-c-Met [pYpY1234/1235] polyclonal antibody is specific to human and canine c-Met [pYpY1234/1235] and expected to react with mouse and rat (100% homology). c-Met (Hepatocyte Growth Factor receptor) is a ~ 145 kDa receptor tyrosine kinase and is required for cell migration and morphogenic differentiation. Validated application for rabbit anti-c-Met [pYpY1234/1235] polyclonal antibody is Western blot. Other applications may work but have not been tested.• Applications: Validated application for rabbit anti-c-Met [pYpY1234/1235] polyclonal antibody is Western blot. • Host species and isotype: The host species and isotype of the c-Met [pYpY1234/1235] polyclonal antibody is rabbit IgG. • Reactivity: Rabbit anti-c-Met [pYpY1234/1235] polyclonal antibody detects human and canine (mouse and rat) c-Met [pYpY1234/1235]. • Product size: Rabbit anti-c-Met [pYpY1234/1235] polyclonal antibody is available in 10 blots pack size.c-Met (Hepatocyte Growth Factor receptor) is a ~145 kDa receptor tyrosine kinase and is required for cell migration and morphogenic differentiation. c-Met receptor is activated in response to scatter factor (SF)/hepatocyte growth factor (HGF) binding. Activated c-Met undergoes dimerization and phosphorylation on multiple residues within the juxtamembrane, catalytic core and cytoplasmic tail domains, thereby regulating receptor internalization, catalytic activity and multisubstrate docking. c-Met contains three tyrosines (Tyr-x-x-x-Tyr-Tyr motif) within the activation loop of the catalytic domain, for which phosphorylation of all three (tyrosines 1230, 1234, and 1235) is required for full activation. Activation of the c-Met/HGF receptor results in binding and/or phosphorylation of many intracellular signaling proteins including multiple adaptor proteins (e.g., Grb2, Shc, Cbl, Crk, cortactin, paxillin, and GAB1), and a variety of other signal transducers (e.g., PI 3-kinase, FAK, Src, ERK1&2, JNK1&2, PLC-γ, and STAT3). 详细说明 常用规格

Reactivity:	Rat, Canine, Mouse, Human
Validated Application:	Western Blot
Host:	Rabbit
SubClass (Isotype):	IgG
Clonality:	Polyclonal
Target Gene:	c-MET [pYpY1234/1235]
Gene ID:	4223, 403438
Label or Dye:	Unconjugated
Target Modification State:	Phospho
Product Size:	10 Blots
Shipping Condition:	Approved for shipment on Wet or Dry Ice
Regulatory Statement:	For Research Use Only. Not for use in diagnostic procedures.

内容和储存

Store in freezer (-5 to -30°C).