货号：10395HNAE250

品牌：ThermoFisher /Invitrogen/ Gibco/ ABI

规格：250 UG

目录价：￥10195.00

市场价格：￥9175.50

会员价格：￥9175.50

金山科研平台，产品价格货期咨询微信：jinshanbio 描述 Manufactured by Sino Biological (China); Distributed by Life Technologies. Interleukin 6 (IL-6) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure and performing cell based assays. It can also be used as an immunogen, as a protein standard, or in other research applications.This recombinant protein is expressed from a DNA sequence encoding the mature form of human IL6 (NP_000591.1) (Val 30-Met 212) retaining the initial Met at the N-terminus.N-terminal Sequence Analysis: Met.Activity:1. Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL6 (100 µL/well of a 8 µg/mL solution) has been shown to bind recombinant human IL6R with a linear range of 1.25-20.0 ng/mL.2. Measured in a cell proliferation assay using TF1 human erythroleukemic cells. The EC₅₀ for this effect is typically 0.2-0.8 ng/mL.Formulation: lyophilized in 140 mM NaCl, 2.7 mM KCl, 10 mM Na₂HPO₄, 1.8 mM KH₂PO₄, pH 7.4, 5% mannitol, 5% trehalose, 0.02% Tween®-80.Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.Expiration Date: expires one year from date of receipt when stored as instructed.BackgroundInterleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity. IL-6 is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule with the molecular mass of 22 kDa-28 kDa. Three IL-6 signaling pathways (STAT1, STAT3, and Ras-dependent MAPK cascade) have been reported. Dysregulated production of IL-6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis.You may also be interested in the following IL6 products: ELISA KitsPrimary AntibodiesGene Expression Assays 规格

Form:	Lyophilized
Purity:	≥ 95% by SDS-PAGE
Species:	Human
Expression:	E. coli
Gene Symbol:	IL6
Gene Aliases:	BSF2, HGF, HSF, IFNB2, IL-6
Product Size:	5 x 50 µg
Protein Form:	Full Length,Recombinant
Protein Family:	Cytokines & Receptors
Protein Subtype:	Interleukins
Molecular Weight:	20.3 kDa
Research Category:	Immunology,Inflammation,Oncology
Protein Tag or Fusion:	Untagged
Validated Application:	Assay Standard

内容及储存 Includes 5 vial of lyophilized protein. Store at -20 °C.