货号：560007

品牌：BD Pharmingen

规格：1EA

目录价：￥3099.00

市场价格：￥1952.37

会员价格：￥1704.45

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ATM is the gene that is mutated in ataxia telangiectasia, an autosomal recessive hereditary disease that is characterized by delayed motor and sexual development, weakened immunity, multiple skin changes, increased sensitivity to ionizing radiation, and increased risk of developing certain cancers. The protein encoded by ATM is a phophoinositide-3-kinase-related protein kinase that is found in the nucleus and is responsible for early responses to the changes in chromatin structure caused by DNA double-strand breaks. Inactive wild type ATM protein forms homodimers or higher order multimers in which the C-terminal kinase domains are inhibited. It has been proposed that multimeric ATM is recruited to DNA double-strand breaks through interactions between its N-terminal HEAT domains and specific chromatin protein complexes. The inhibition of the kinase domains is lifted, resulting in auto-phosphorylation of the ATM at a single serine site and disruption of the multimers. The phosphorylated state of ATM is a rapid and highly sensitive indicator that cells have been exposed to agents that cause DNA double-strand breaks. The kinase domains of the resulting ATM monomers are accessible to a wide variety of substrates that are involved in DNA repair, cell-cycle regulation, and apoptosis. Thus ATM is a central regulator of cellular responses to ionizing radiation, and cells that lack ATM undergo radioresistant DNA synthesis and are resistant to γ radiation-induced apoptosis.The K88-534 monoclonal antibody recognizes human ATM phosphorylated at serine 1981 (S1981) and mouse ATM phosphorylated at its orthologous site, S1987.

Catalog Number

560007

Brand

BD Pharmingen™

Name

ATM (pS1981)

Concentration

0.5 mg/ml

Size

0.1mg

RegulatoryStatus

RUO

Clone

K88-534

Format

Purified

Isotype

IgG_2b, κ

W.B. Positive Control

none

Molecular Weight

349 kDa

Immunogen

Phosphorylated Mouse ATM Peptide

Strain Host

BALB/c

Reactivity

QC Testing : HumanTested in Development : Mouse

Applications

Bioimaging	- Routinely Tested
Western Blot	- Reported